Results 91 to 100 of about 7,350,414 (235)

From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity

Brain Pathology, EarlyView.
How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova, Ondrej Bernatik, Katarina Cimborova, Martin Barak, Michal Hendrych, Karolina Kocourkova, Marie Sulcova, Jaroslav Olha, Katerina Amruz Cerna, Zdenek Hodny, Radim Jancalek, Dasa Bohaciakova   +11 more
wiley   +1 more source

Clinical and prognostic significance of tumor markers cytokeratin 19 fragment, carcinoembryonic antigen, and neuron-specific enolase in lung cancer [PDF]

, 2005
OBJECTIVE: To evaluate the clinical and prognostic significance of the tumor markers cytokeratin 19 fragment, carcinoembryonic antigen and neuron-specific enolase in lung cancer patients.
Malakauskas, Kęstutis, Fischer, Jürgen Richard, Muley, Thomas, Žemaitis, Marius, Sakalauskas, Raimundas, Lahm, Harald   +5 more
core  

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury, both in vivo and in vitro

Neural Regeneration Research, 2018
Neural stem cells have great potential for the development of novel therapies for nervous system diseases. However, the proliferation of endogenous neural stem cells following brain ischemia is insufficient for central nervous system self-repair ...
Pei-Dong Zheng, Rajneesh Mungur, Heng-Jun Zhou, Muhammad Hassan, Sheng-Nan Jiang, Jie-Sheng Zheng   +5 more
doaj   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Prolonged Elevation of Serum Neuron-Specific Enolase in Children After Clinical Diagnosis of Brain Death

, 2011
To elucidate the time course of neuronal cell death after the clinical criteria for brain death are met, the authors reviewed serial changes of serum neuron-specific enolase levels in 3 children (age range, 3-15 years) clinically diagnosed as brain dead
Yukiko Mogami, Yausihisa Toribe, Yasuhiro Suzuki, Keiko Yanagihara, Keitaro Yamada, Ikuko Hirata, Toshiyuki Mano   +6 more
core   +1 more source

Predictive value of S-100β and neuron-specific enolase serum levels for adverse neurologic outcome after cardiac surgery [PDF]

, 2000
Objectives: The aim of this study was to evaluate the time course of S-100β and neuron-specific enolase serum levels after cardiac surgery and their clinical relevance in predicting postoperative adverse neurologic outcomes; the 2 proteins are only ...
Zerkowski, Hans-Reinhard, Georgiadis, Dimitrios, Börner, Angelika, Deufel, Thomas, Kowatscheva, Ellen, Schulte-Mattler, Wilhelm, Lautenschläger, Christine, Lindner, Alfred, Bergera, Anja, Zierz, Stephan   +9 more
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Predictive values of neuron-specific enolase (NSE) for poor outcome after out-of-hospital cardiac arrest.

, 2017
Predictive values of neuron-specific enolase (NSE) for poor outcome after out-of-hospital cardiac arrest.
Michael Wanscher (706395), Jan Hovdenes (3666277), Anders Åneman (3666271), Sebastian Wiberg (3530822), Yvan Gasche (3576845), Niklas Nielsen (456082), John Bro-Jeppesen (706393), David Erlinge (43626), Matthew P. Wise (3666286), Janneke Horn (474013), Pascal Stammet (3666283), Tommaso Pellis (3558899), Tobias Cronberg (3666274), Jesper Kjaergaard (706394), Jørn Wetterslev (149392), Yvan Devaux (161537), Jakob Hartvig Thomsen (3666280), Hans Friberg (3666289), Michael Kuiper (37208), Christian Hassager (706396), Matilde Winther-Jensen (3666268)   +20 more
core   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source