Results 81 to 90 of about 7,357,818 (235)

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Clinical and prognostic significance of tumor markers cytokeratin 19 fragment, carcinoembryonic antigen, and neuron-specific enolase in lung cancer [PDF]

, 2005
OBJECTIVE: To evaluate the clinical and prognostic significance of the tumor markers cytokeratin 19 fragment, carcinoembryonic antigen and neuron-specific enolase in lung cancer patients.
Malakauskas, Kęstutis, Fischer, Jürgen Richard, Muley, Thomas, Žemaitis, Marius, Sakalauskas, Raimundas, Lahm, Harald   +5 more
core  

Electrochemical aptasensors for ultrasensitive multiplexed detection: Towards a new era of precision diagnostics and environmental monitoring

VIEW, EarlyView.
Electrochemical aptasensors are emerging as powerful platforms for precision diagnostics and environmental monitoring, owing to their high selectivity, programmability and compatibility with miniaturised systems. However, their broader application is constrained by limited signal intensity and challenges in reliable multiplexed detection.
Azadeh Abdi, Ngoan Thi Thao Nguyen, Riccardo Zulli, Jacopo Giaretta, Fariba Dehghani, Syamak Farajikhah   +5 more
wiley   +1 more source

Initial V‐A ECMO Flow‐Index and Its Association With Inflammation, Organ Failure, and Outcomes

Artificial Organs, EarlyView.
Higher initial V‐A ECMO flow‐index was associated with greater shock severity and independently associated with multi‐organ failure. Early hemolysis may partly contribute to this association, particularly in eCPR patients, whereas no significant indirect effect through IL‐6 was observed.
Kostiantyn Kozakov, Zdenek Provaznik, Alois Philipp, Maik Foltan, Christian Schach, Sergey Vasin, Andreas Keyser, Leopold Rupprecht, Christof Schmid, Simon Schopka   +9 more
wiley   +1 more source

Prolonged Elevation of Serum Neuron-Specific Enolase in Children After Clinical Diagnosis of Brain Death

, 2011
To elucidate the time course of neuronal cell death after the clinical criteria for brain death are met, the authors reviewed serial changes of serum neuron-specific enolase levels in 3 children (age range, 3-15 years) clinically diagnosed as brain dead
Yukiko Mogami, Yausihisa Toribe, Yasuhiro Suzuki, Keiko Yanagihara, Keitaro Yamada, Ikuko Hirata, Toshiyuki Mano   +6 more
core   +1 more source

Predictive value of S-100β and neuron-specific enolase serum levels for adverse neurologic outcome after cardiac surgery [PDF]

, 2000
Objectives: The aim of this study was to evaluate the time course of S-100β and neuron-specific enolase serum levels after cardiac surgery and their clinical relevance in predicting postoperative adverse neurologic outcomes; the 2 proteins are only ...
Zerkowski, Hans-Reinhard, Georgiadis, Dimitrios, Börner, Angelika, Deufel, Thomas, Kowatscheva, Ellen, Schulte-Mattler, Wilhelm, Lautenschläger, Christine, Lindner, Alfred, Bergera, Anja, Zierz, Stephan   +9 more
core   +1 more source

Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury, both in vivo and in vitro

Neural Regeneration Research, 2018
Neural stem cells have great potential for the development of novel therapies for nervous system diseases. However, the proliferation of endogenous neural stem cells following brain ischemia is insufficient for central nervous system self-repair ...
Pei-Dong Zheng, Rajneesh Mungur, Heng-Jun Zhou, Muhammad Hassan, Sheng-Nan Jiang, Jie-Sheng Zheng   +5 more
doaj   +1 more source

From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity

Brain Pathology, EarlyView.
How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova, Ondrej Bernatik, Katarina Cimborova, Martin Barak, Michal Hendrych, Karolina Kocourkova, Marie Sulcova, Jaroslav Olha, Katerina Amruz Cerna, Zdenek Hodny, Radim Jancalek, Dasa Bohaciakova   +11 more
wiley   +1 more source

Predictive values of neuron-specific enolase (NSE) for poor outcome after out-of-hospital cardiac arrest.

, 2017
Predictive values of neuron-specific enolase (NSE) for poor outcome after out-of-hospital cardiac arrest.
Michael Wanscher (706395), Jan Hovdenes (3666277), Anders Åneman (3666271), Sebastian Wiberg (3530822), Yvan Gasche (3576845), Niklas Nielsen (456082), John Bro-Jeppesen (706393), David Erlinge (43626), Matthew P. Wise (3666286), Janneke Horn (474013), Pascal Stammet (3666283), Tommaso Pellis (3558899), Tobias Cronberg (3666274), Jesper Kjaergaard (706394), Jørn Wetterslev (149392), Yvan Devaux (161537), Jakob Hartvig Thomsen (3666280), Hans Friberg (3666289), Michael Kuiper (37208), Christian Hassager (706396), Matilde Winther-Jensen (3666268)   +20 more
core   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source