Results 131 to 140 of about 1,033,935 (249)

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source

Commentary: Analysis of SUMO1-conjugation at synapses

Frontiers in Cellular Neuroscience, 2017
Kevin A. Wilkinson, Stéphane Martin, Shiva K. Tyagarajan, Ottavio Arancio, Tim J. Craig, Chun Guo, Paul E. Fraser, Steven A. N. Goldstein, Jeremy M. Henley   +8 more
doaj   +1 more source

Brain rewiring during development: A comparative analysis of larval and adult <i>Drosophila melanogaster</i> connectomes. [PDF]

Netw Neurosci
Yadav P, Shinde P, Singh A.
europepmc   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Ventral tegmental area GABA neurons integrate positive and negative valence. [PDF]

Nat Commun
Stelzner ME, Wolff AR, Saunders BT.
europepmc   +1 more source

Resolving rates of mutation in the brain using single-neuron genomics

, 2016
Gilad D. Evrony, Eunjung Lee, Peter J. Park, Christopher A. Walsh   +3 more
openalex   +1 more source

Critical Roles of Embryonic Born Dorsal Dentate Granule Neurons for Activity-Dependent Increases in BDNF, Adult Hippocampal Neurogenesis, and Antianxiety-like Behaviors

, 2020
Dong Sun, Leena Milibari, Jin‐Xiu Pan, Xiao Ren, Ling-Ling Yao, Yang Zhao, Chen Shen, Wenbing Chen, Fu‐Lei Tang, Daehoon Lee, Jun-Shi Zhang, Lin Mei, Wen‐Cheng Xiong   +12 more
openalex   +2 more sources

Computational cannula microscopy of neurons using neural networks [PDF]

, 2020
Ruipeng Guo, Zhimeng Pan, Andrew Taibi, Jason Shepherd, Rajesh Menon, Ruipeng Guo, Zhimeng Pan, Andrew Taibi, Jason Shepherd, Rajesh Menon   +9 more
openalex   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Tau pathology in the brainstem monoaminergic neurons reflect resilience to Alzheimer's disease pathology in the Nun study cases. [PDF]

Acta Neuropathol Commun
Pezhouh MK, Chen G, Meints J, Hemmy LS, SantaCruz KS, Lee MK.   +5 more
europepmc   +1 more source