Results 271 to 280 of about 1,725,183 (344)

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source

LRRK2 G2019S mutation contributes to mitochondrial transfer dysfunction in a Drp1-STX17-dependent manner. [PDF]

Transl Neurodegener
Ding M, Wang F, Jiang LL, Ma C, Qi YW, Liu JY, Li J, Wang MX, Jin H, Zhang JR, Mao CJ, Li XK, Liu CF, Cheng XY.   +13 more
europepmc   +1 more source

FOXP3 Polymorphism and Upregulation of the CXCL12‐CXCR4‐SNAIL Axis with High Infiltration of M2TAM by STAT3/NFKB Pathways Influence the Survival of Cervical Cancer Patients

Advanced Biology, EarlyView.
This study highlights how cervical carcinoma progression is shaped by immune–tumor interactions within the TME. M2‐TAM infiltration, regulated through STAT3/NF‐κB and linked to CXCL12–CXCR4, promotes immune suppression, angiogenesis, and poor survival.
George A. Lira, Fábio M. de Azevedo, Ingrid G. S. Lins, Janaína C. O. Crispim, Giovanna A. Lira, Rômulo S. Cavalcante, Ricardo Cobucci, Carolina O. Mendes‐Aguiar, Rafaela Torres Dantas Da Silva, Vinícius E. da Silva, Ryan C. Q. Aquino, Raimundo F. Araújo Júnior   +11 more
wiley   +1 more source

Redox regulation of memory formation by Rrp1 in <i>Drosophila</i>. [PDF]

Proc Natl Acad Sci U S A
Hsu CT, Chen CC, Hung YL, Yang YT, Chiu YH, Fong SS, Yang JH, Wu ZW, Liou JW, Lin HW, Feng KL, Yang JL, Chiang AS.   +12 more
europepmc   +1 more source

Brain rewiring during development: A comparative analysis of larval and adult <i>Drosophila melanogaster</i> connectomes. [PDF]

Netw Neurosci
Yadav P, Shinde P, Singh A.
europepmc   +1 more source

Single-cell transcriptomics reveals probiotic reversal of neonatal morphine-induced gene disruptions underlying adolescent pain hypersensitivity. [PDF]

Commun Biol
Tao J, Antoine D, Jalodia R, Valdes E, Boyles SM, Hulme W, Roy S.   +6 more
europepmc   +1 more source

Divergent prefrontal cortex circuits regulate cued food seeking under distinct metabolic or emotional states. [PDF]

Nat Commun
Zhang XO, Aquino-Miranda G, Cho CE, Wang Y, Ha DH, Elinson-Watson N, Dong A, Kemere C, Do-Monte FH.   +8 more
europepmc   +1 more source

Targeting and anchoring the mechanosensitive ion channel Piezo to facilitate its inhibition of axon regeneration. [PDF]

PLoS Genet
Wang Q, Miles L, Wang S, Ryll LM, Noristani HN, Schauer E, Monahan Vargas EJ, Powell J, O'Rourke-Ibach SJ, Akizu N, Wildonger J, Li S, Song Y.   +12 more
europepmc   +1 more source

Tau pathology in the brainstem monoaminergic neurons reflect resilience to Alzheimer's disease pathology in the Nun study cases. [PDF]

Acta Neuropathol Commun
Pezhouh MK, Chen G, Meints J, Hemmy LS, SantaCruz KS, Lee MK.   +5 more
europepmc   +1 more source