Results 201 to 210 of about 1,846,055 (403)

Increased mGluR5 in somatostatin-positive interneurons mediates deactivation of the mPFC in a mouse model of neuropathic pain

Experimental and Molecular Medicine
Understanding the neurobiological alterations associated with neuropathic pain is crucial for treatment interventions, but the underlying mechanisms remain unclear.
Mirae Jang, Jaegeon Lee, Seung Ha Kim, Sang Ho Yoon, Myoung-Hwan Kim, Yong-Seok Lee, Sun Kwang Kim, Geehoon Chung, Sang Jeong Kim   +8 more
doaj   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Rapid Isolation of Dorsal Root Ganglion Macrophages. [PDF]

, 2019
There are growing interests to study the molecular and cellular interactions among immune cells and sensory neurons in the dorsal root ganglia after peripheral nerve injury.
Guan, Zhonghui, Leff, Jacqueline, Yu, Xiaobing   +2 more
core  

A Retrospective Analysis Into the Effect of Punch Grafts in Patients With Chronic Ulcers of the Lower Leg

JEADV Clinical Practice, EarlyView.
Punch grafting was retrospectively evaluated in patients with chronic lower leg ulcers treated at Erasmus MC between 2018 and 2023. Median pain scores significantly decreased after 6 weeks. Opioid use declined and 30% of patients no longer required analgesics. Complete wound closure was achieved in 7% of cases.
M. van Zanten, J. E. Geskes, M. M. E. Thung, P. Velthuis, C. van Montfrans   +4 more
wiley   +1 more source

Stable dose cannabinoid medicine (Sativex®, THC+CBD) can provide sustained efficacy in the treatment of refractory painful diabetic neuropathy or other peripheral neuropathic pain associated with allodynia [poster] [PDF]

, 2008
No abstract ...
Hoggart, B., Ratcliffe, S., Serpell, M.G., Simpson, K.   +3 more
core  

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai, Hao Qin, Yoon Bin Chong, I‐Hsiang Chen, Shih‐Hsun Kuo, Tzu‐Ting Tseng, Ann‐Shung Lieu   +6 more
wiley   +1 more source

Transcranial magnetic resonance imaging–guided focused ultrasound: noninvasive central lateral thalamotomy for chronic neuropathic pain [PDF]

, 2011
Daniel Jeanmonod, Beat Werner, Anne Morel, Lars Michels, Eyal Zadicario, Gilat Schiff, Ernst Martin   +6 more
openalex   +1 more source

Quadriceps, hamstring and patella tendon autografts for primary anterior cruciate ligament reconstruction demonstrate similar clinical outcomes, including graft failure, joint laxity and complications: A systematic review with meta‐analysis of randomised controlled trials

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Graft failure following anterior cruciate ligament reconstruction (ACLR) remains a significant challenge, driving discussion for optimal graft choice. Traditionally, hamstring tendon (HT) and bone‐patella tendon‐bone (BPTB) autografts have been favoured for ACLR. Recently, quadriceps tendon (QT) usage has increased.
Ty White, Matthew Castro, Lucas Antonio, Wayne Hing, Francois Tudor, Larissa Sattler   +5 more
wiley   +1 more source

Assessment and Treatment of Psychosocial Comorbidities in Patients With Neuropathic Pain [PDF]

, 2010
Dennis C. Turk, Joseph Audette, Robert M. Levy, Sean Mackey, Steven P. Stanos   +4 more
openalex   +1 more source