Results 201 to 210 of about 114,925 (309)

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Perioperative Treatment of Neuropathic Pain (Nerve SPACE 2025). [PDF]

J Hand Surg Glob Online
Mosa A, Li NY, Chamessian A, Crock LW, Curtin CM, Belzberg A, Buday S, Loeffler BJ, Janney C, Mahan MA, Moore AM.   +10 more
europepmc   +1 more source

Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators

British Journal of Pharmacology, EarlyView.
Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo, Thomas M. Hammond, Alice W. Wang, Caroline K. Wang, Varun Aggarwal, Shawn M. Lamothe, Harley T. Kurata   +6 more
wiley   +1 more source

Maladaptive reorganization of mediodorsal thalamus as a central mechanism in neuropathic pain-related sleep disorders. [PDF]

Mil Med Res
Li L, Han Q, Bai HL, Xiao Q, He X, Chen JF, Zhen ZM, Luo XQ, Zhang YJ, Lu MM, Wang X, Li SY, Xiong JX, Wang Y, Hu ZA, Zhang XL, Liu Y, He C.   +17 more
europepmc   +1 more source

Exclusion criteria in clinical trials of treatments for neuropathic pain: a systematic analysis. [PDF]

Front Pain Res (Lausanne)
Salcedo R, Moghadam R, Saneifard S, Zhou A, Salmasi V.   +4 more
europepmc   +1 more source

Effects of FGF4/HIF-1α axis-mediated neuronal glycolysis on neuropathic pain. [PDF]

J Headache Pain
Wu Q, Chen Y, Yao X, Ren S, Xie H, Li S, Ying X, Wang X.   +7 more
europepmc   +1 more source

Expert considerations to guide the development and delivery of an exercise intervention in people with type 2 diabetes‐related foot ulcer disease

Diabetic Medicine, EarlyView.
Abstract Objective Engaging in exercise presents unique challenges for those with type 2 diabetes (T2D) and diabetes‐related foot ulcer disease (DFUD). This brief report describes the development of practical considerations aiming to support exercise in people with T2D and DFUD.
Vicki L. Johnson, Vicky Hall, Rachel Berrington, Julia Burdon, Sally Schreder, Matthew McCarthy, Chris Brough, Patrick J. Highton, Michelle Hadjiconstantinou, Frances L. Game, Lisa J. Keogh, Solomon Tesfaye, Jonathan Valabhji, John R. Petrie, Ketan K. Dhatariya, Tom Yates, Melanie J. Davies, Kamlesh Khunti   +17 more
wiley   +1 more source

Efficacy and safety of gabapentinoid combination therapy versus monotherapy for the treatment of neuropathic pain. [PDF]

Front Physiol
Li D, He Y, Fan Z, Chen Z, Deng G, Ouyang L.   +5 more
europepmc   +1 more source

Subcutaneous Incobotulinumtoxin-A for Refractory Central Post-Stroke Neuropathic Pain: A Report of Two Cases. [PDF]

Toxins (Basel)
Carda S, Grana E.
europepmc   +1 more source

Diabetic Corneal Neuropathy as a Window Into Diabetic Foot Risk: A Large‐Scale Association Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To evaluate the association between diabetic corneal neuropathy and diabetic foot risk by examining corneal nerve features, clinical characteristics, and tear mediators in patients with different diabetic foot risk categories. Methods In this cross‐sectional study, 710 participants underwent diabetic foot examination, in vivo confocal ...
Chang Liu, Mingyi Yu, Isabelle Xin Yu Lee, Gavin Patrick O'Donnell, Hong Chang Tan, Aya Takahashi‐Nakajima, Yixin Wang, Mui Hui Koh, Ho Sean Matthew Chung‐Hei, Hasika Wickrama Senevirathne, Hla Myint Htoon, Ching‐Yu Cheng, Yu‐Chi Liu   +12 more
wiley   +1 more source