Results 201 to 210 of about 1,094,883 (299)

First‐In‐Human Study of Mirogabalin (BM2216) Sustained‐Release Tablets: Safety, Tolerability, Pharmacokinetics, Food Effect and Dose Proportionality With Comparison to Mirogabalin Besylate in Healthy Participants

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To characterise the pharmacokinetics (PKs) and safety of BM2216 sustained‐release (SR) tablets after single‐dose oral administration under fasted/fed conditions in healthy participants, assess the effect of food and dose proportionality, and compare the single and multiple‐dose PK of BM2216 SR tablets with mirogabalin besylate tablets to ...
Peiyang Song, Hongtao Zhao, Mingxue Zhu, Lei Wan, Yuan Chen, Zhongping Li, Chengyong Tang   +6 more
wiley   +1 more source

Transcriptomic signatures of the insular cortex in a mouse model of neuropathic pain. [PDF]

Front Mol Neurosci
Bai Y, Yao GQ, Jiang CG, Zhang C, Diao YG, Feng SZ, Liang GB, Qiu XT, Jiang W.   +8 more
europepmc   +1 more source

Prevalence and Disability of Peripheral Neuropathy in Patients With Waldenström's Macroglobulinemia

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Peripheral neuropathy (PN) is considered a frequent complication of Waldenström's macroglobulinemia (WM). Establishing a causal relationship between PN and WM is complicated by confounding factors such as age‐related axonal loss and diabetes. This scoping review aims to summarize the current evidence on WM‐associated PN with a focus
Morten Müller Aagaard, Kristoffer Nagy Skaastrup, Louise Sloth Kodal, Britt Stævnsbo Pedersen, Troels Hammer, John Vissing, Tina Dysgaard   +6 more
wiley   +1 more source

Piezo1 in neuropathic pain: a putative mechanotransduction hub and underlying mechanisms. [PDF]

Front Mol Neurosci
Liu K, Li C, Ma W, Zhao W, Sun R, Zheng Y, Zhao Q, Yang J, Lyn L.   +8 more
europepmc   +1 more source

Computed tomographic diagnosis and treatment of pneumolabyrinth in a mare with temporohyoid osteoarthropathy

Equine Veterinary Education, EarlyView.
Summary Pneumolabyrinth, which is the presence of gas within the labyrinth of the inner ear, can be associated with severe peripheral vestibular signs. This report describes a case of pneumolabyrinth in a horse that presented with vestibular ataxia. An 8‐year‐old Quarter Horse mare that presented with cranial nerve VII deficits underwent a standing ...
C. A. Jamieson, J. Jarvis, O. Nagasaka, M. Murakami, C. V. Fulkerson, A. C. B. C. F. Pinto   +5 more
wiley   +1 more source

Temporal Transcriptomic Changes in the Cingulate Cortex of Neuropathic Pain Mice. [PDF]

Biomedicines
Yao GQ, Yuan ZR, Qiu XT, Jiang CG, Zhang C, Feng SZ, Piao GX, Ma H, Zhu ZH, Diao YG, Fregni F, Bai Y.   +11 more
europepmc   +1 more source

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Comment on "Lesion Without Pain, Pain Without Certainty: A Critical Reappraisal of the NeuPSIG Diagnostic Algorithm for Neuropathic Pain". [PDF]

Eur J Pain
Finnerup NB, Gylfadottir SS.
europepmc   +1 more source

Chronic pruritus treated with alendronate in bilateral striopallidodentate calcinosis associated with an SLC20A2 gene mutation

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Adrien Boyard, Florian Stéphan, Boris Chaumette, Mathilde Moreau, Laure Bleton, Nicolas Hornez, Steeve Genestet, Jérémy Betrand, Amélie Bourhis, Morgane Le Bon‐Jégo, Thierry Bienvenu, Camille Verebi, Laurent Misery   +12 more
wiley   +1 more source

Defining cellular mechanisms important for painful chemotherapy‐related neuropathy using long‐term primary cultures of nociceptors

The FEBS Journal, EarlyView.
Basic excitability alterations that drive irregular spontaneous activity in primary nociceptors during chemotherapy‐induced peripheral neuropathy. Using an in vitro model of repeated paclitaxel application to dorsal root ganglion neurons that produces progressive axonal degeneration, Lamberti and colleagues show that all three basic excitability ...
Edgar T. Walters
wiley   +1 more source