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Revisiting the neuropathogenesis of Zellweger syndrome
Neurochemistry International, 2014 Zellweger syndrome (ZS) is a neonatal-lethal genetic disease that affects all tissues, and features neuropathology that involves primary developmental defects as well as neurodegeneration.
Denis I Crane
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Virology, 2012 Enterovirus 71 (EV71) is a major pathogen that causes hand–foot–mouth disease (HFMD). Our previous studies have demonstrated that the complete process of pathogenesis, which may include tissue damage induced by host inflammatory responses and direct ...
Erxia Yang, Yanchun Che, Hong Zhao
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Neuroimaging the Neuropathogenesis of HIV
Current HIV/AIDS Reports, 2021This review highlights neuroimaging studies of HIV conducted over the last 2 years and discusses how relevant findings further our knowledge of the neuropathology of HIV. Three major avenues of neuroimaging research are covered with a particular emphasis on inflammation, aging, and substance use in persons living with HIV (PLWH).Neuroimaging has been a
Anna H, Boerwinkle +3 more
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Molecular Medicine Today, 1996
Neurological disease directly attributable to HIV-1 infection (HIV dementia) is one of the most frequent disorders in persons with AIDS. HIV-1 dementia is associated with neuronal loss, but occurs in the absence of direct viral infection of neurons, suggesting that neurological damage occurs by an indirect mechanism.
S, Dewhurst, H A, Gelbard, S M, Fine
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Neurological disease directly attributable to HIV-1 infection (HIV dementia) is one of the most frequent disorders in persons with AIDS. HIV-1 dementia is associated with neuronal loss, but occurs in the absence of direct viral infection of neurons, suggesting that neurological damage occurs by an indirect mechanism.
S, Dewhurst, H A, Gelbard, S M, Fine
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Developments in HIV Neuropathogenesis
Current Pharmaceutical Design, 2006Despite the fact that neurons are rarely infected by the human immunodeficiency virus (HIV), neuronal loss is common in patients with HIV infection, likely due to the effects of viral proteins and inflammatory mediators on these cells. Despite the widespread use of highly active antiretroviral therapy (HAART), at least in developed nations, cognitive ...
Jeffrey A, Rumbaugh, Avindra, Nath
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Journal of Neuroimmune Pharmacology, 2010
In humans, exogenous retroviruses are known to cause immunodeficiency and neurological disease. While endogenous retroviruses are firmly established pathogens in other species, the human endogenous retroviruses (HERVs) may well be considered as emerging pathogens.
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In humans, exogenous retroviruses are known to cause immunodeficiency and neurological disease. While endogenous retroviruses are firmly established pathogens in other species, the human endogenous retroviruses (HERVs) may well be considered as emerging pathogens.
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Unravelling the neuropathogenesis of Japanese encephalitis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2007Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia. Mortality rates can be as high as 30%, with one-third of survivors suffering severe neurological sequelae.
Khin Saw Aye, Myint +3 more
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Update on the Neuropathogenesis of Delirium
Dementia and Geriatric Cognitive Disorders, 1999Delirium has been considered a syndrome of generalized dysfunction of higher cortical functions due to its breadth of symptoms and associated diffuse slowing on electroencephalogram. Advances in neuropsychiatry have revealed differences between brain regions, including the hemispheres, which may underlie the constellation of symptoms among different ...
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The neuropathogenesis of delirium
Reviews in Clinical Gerontology, 2002Delirium is a common disorder in ill older patients, characterized by a fluctuating disturbance of consciousness and changes in cognition that develop over a short period of time. Studies have shown that delirium is an independent predictor of increased length of hospital stay, and is associated with increased dependency and mortality, as well as being
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