Results 141 to 150 of about 64,926 (256)

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Dual Targeting Approach Using 4-Hydroxytamoxifen Neuropeptide Y Conjugates for Selective Addressing of Adipose Tissue. [PDF]

ChemMedChem
Kohler A, Jülke EM, Darveniza LC, Stichel J, Beck-Sickinger AG.   +4 more
europepmc   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Differences in serum neuropeptide Y levels and appetite changes in patients with major depressive disorder stratified by sex and reproductive aging. [PDF]

BMC Psychiatry
Yuan Q, Wang L, Zhuang Y, Lin D, Xu Z, Wen C, Su W, Huang Z, Qiu Y.   +8 more
europepmc   +1 more source

Risks Associated With Benzodiazepine Long‐Term Use in Chronic Insomnia: A Systematic Review and (Network) Meta‐Analysis

Journal of Sleep Research, EarlyView.
ABSTRACT This systematic literature review evaluated the risks of using benzodiazepine medications for more than 3 months in adults with chronic insomnia. Chronic insomnia is defined as ongoing dissatisfaction with sleep quantity or quality, causing significant distress and impaired functioning during the day.
Dieter Riemann, Chiara Baglioni, Christoph Nissen, Agathe Nevière, Omar Irfan, Pauline Le Nouveau, Chrysoula Leontiou, Damien Léger   +7 more
wiley   +1 more source

Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) Neurons. [PDF]

Obesity (Silver Spring)
Minbashi Moeini M, Lavoie O, Caron A, Williams KW, Michael NJ.   +4 more
europepmc   +1 more source

Does Sleep Curtailment Stimulate Appetite, Motivation to Eat and Dietary Intake in Humans? A Narrative Synthesis of Evidence and Considerations for Future Studies

Journal of Sleep Research, EarlyView.
ABSTRACT Insufficient sleep has been increasingly recognised as a risk factor for obesity, yet the underlying mechanisms remain incompletely understood. Research suggests that sleep restriction promotes excessive dietary intake, and it is commonly assumed that this relationship can be explained by appetite dysregulation.
Sze‐Yen Tan, Isabella Emillya Tjahjono, Ilili Feyesa, Jeew Hettiarachchi, Nahyun Kim, Reagan Pennycuff, Amani Qawasmeh, Robin M. Tucker   +7 more
wiley   +1 more source

Intranasal Application of Peptides Modulating the Neuropeptide Y System. [PDF]

ACS Pharmacol Transl Sci
Jülke EM, Özbay B, Nowicki M, Els-Heindl S, Immig K, Mörl K, Bechmann I, Beck-Sickinger AG.   +7 more
europepmc   +1 more source

Targeting Orexin 2 Receptors in Idiopathic Hypersomnia and Narcolepsy: A Randomised Phase 1b Proof‐Of‐Concept Study of Alixorexton

Journal of Sleep Research, EarlyView.
Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein, Brendon J. Yee, Julia L. Chapman, Jian Eu Tai, Sheila Sivam, Craig Hopkinson, Daniel G. Smith, Alexandra Lovett, Shifang Liu, Sergey Yagoda, Bhaskar Rege   +10 more
wiley   +1 more source

Investigating the role of melanocortinergic, glutamatergic and neuropeptide Y systems on hypophagia caused by gastric inhibitory polypeptide (GIP) in broilers. [PDF]

Poult Sci
Gharaie ML, Zendehdel M, Zarei H, Mahdavi K.   +3 more
europepmc   +1 more source