Results 101 to 110 of about 219,679 (299)

Variation in Neurodegeneration‐Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Possible pleiotropic effects of apolipoprotein E4 (APOE E4) in individuals with congenital brain malformations are relatively unknown. Our goal was to determine if neurodegeneration‐linked brain region volumes differ significantly between E4 carriers and noncarriers in young adults with spina bifida (SB). Methods Eleven individuals ( 
Joan M. Jasien   +8 more
wiley   +1 more source

Neuropsychological test scores and clinical response to neuroleptic drugs in schizophrenic patients

open access: hybrid, 1992
Robert C. Smith   +3 more
openalex   +1 more source

Factors Influencing the Duration From the Initiation of Surgical Evaluation to Final Intervention in Pediatric Epilepsy Surgery

open access: yesAnnals of the Child Neurology Society, EarlyView.
ABSTRACT Rationale Longer duration of epilepsy before surgery is a predictor of poor outcome. While referral delays of surgical candidates are well documented, factors causing delay during the presurgical evaluation remain unclear and may vary depending on institutional characteristics.
Ruba Al‐Ramadhani   +37 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams   +7 more
wiley   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi   +6 more
wiley   +1 more source

Bistable perception in normal aging: perceptual reversibility and its relation to cognition [PDF]

open access: yes, 2017
The effects of age on the ability to resolve perceptual ambiguity are unknown, though it depends on fronto-parietal attentional networks known to change with age. We presented the bistable Necker cube to 24 middle-aged and older adults (OA; 56–78 years)
Cao, B.   +5 more
core  

Relationship of malnutrition and frailty on prolonged stay at the hospital in heart failure patients

open access: yesESC Heart Failure, EarlyView.
This abstract presents a study of 200 heart failure patients (average age 72.3 years), assessing the relationship between malnutrition and frailty. Nutritional status was evaluated using the Mini Nutritional Assessment: 63.5% had normal nutrition, 35% were at risk, and 1.5% were malnourished.
Katarzyna Lomper   +3 more
wiley   +1 more source

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