Results 301 to 310 of about 13,498,406 (368)
Movement Disorders, EarlyView.Abstract Background Glial cell line–derived neurotrophic factor (GDNF) is required for development and survival of dopaminergic neurons. A previous trial evaluating lower‐dose adeno‐associated virus serotype 2–GDNF (AAV2‐GDNF) bilateral intraputaminal infusion in participants with advanced Parkinson's disease (PD) achieved 26% mean putaminal coverage ...
Amber D. Van Laar +10 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Individual variability in clinical response to dopamine replacement therapy (DRT) is a key barrier to efficacious treatment for patients with Parkinson's disease (PD). A better understanding of the neurobiological sources of such interindividual differences is necessary to personalize DRT prescribing, inform future clinical ...
Alex I. Wiesman +5 more
wiley +1 more source
Neural Mechanisms of Object Location Memory in Huntington's Disease
Movement Disorders, EarlyView.ABSTRACT Background Object‐location memory impairment in Huntington's disease (HD) occurs from premanifest period and declines as HD progresses, however, pathogenesis of object‐location memory is unknown. The striatum and hippocampus are affected in HD, functionally interacting allowing intact object‐location memory.
Yifat Glikmann‐Johnston +4 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background High frequency deep brain stimulation of the subthalamic nucleus (STN‐DBS) is a well‐established therapy for Parkinson's disease (PD) motor symptoms, however, its effect on non‐motor symptoms is controversial. Low frequency DBS can improve cognition, but its effects on motor functions are detrimental.
Lucia Ricciardi +10 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Objective To compare iron deposition in the substantia nigra (SN) as measured with quantitative susceptibility mapping (QSM) on antemortem magnetic resonance imaging (MRI) between individuals with and without Lewy‐related pathology at autopsy. Methods We performed a retrospective cohort study including 54 participants who underwent autopsy and
Patricia Diaz‐Galvan +28 more
wiley +1 more source
Repairing Myelin After Irradiated Pediatric Brain Tumor: A Magnetization Transfer Imaging Analysis
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background While exercise training and metformin treatment have demonstrated preliminary cognitive improvements in pediatric brain tumor (PBT) survivors, the neuronal mechanisms underlying their cognitive improvements are unclear. Diffusion‐weighted metrics (e.g., fractional anisotropy [FA]) are commonly used to evaluate remyelination, but ...
Éloïse Baudou +7 more
wiley +1 more source
Version 3 of the Alzheimer Disease Centers’ neuropsychological test battery in the Uniform Data Set (UDS) [PDF]
, 2018 al., et +2 more
core +1 more source
Assessment of neuropsychological testing [PDF]
Neurology, 1997 To the Editor: I wanted to respond to certain aspects of the recent report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology published in the August 1996 issue of Neurology . For the most part, this special article provides helpful and accurate guidance to neurologists about our field.
Kenneth M. Adams +4 more
+22 more sources