Results 31 to 40 of about 219,679 (299)

Enhanced Brain‐Heart Connectivity as a Precursor of Reduced State Anxiety after Therapeutic Virtual Reality Immersion

Advanced Science, EarlyView.
This study shows that enhanced brain‐to‐heart coupling is a precursor of anxiety reduction following a virtual reality‐based non‐pharmacological intervention. Driven by midline beta rhythms, this effect suggests the involvement of central‐autonomic interactions.
Idil Sezer, Paul Moreau, Mohamad El Sayed Hussein Jomaa, Valérie Godefroy, Bénédicte Batrancourt, Richard Lévy, Anton Filipchuk   +6 more
wiley   +1 more source

Early and Differential Diagnosis of Dementia and Mild Cognitive Impairment Design and Cohort Baseline Characteristics of the German Dementia Competence Network [PDF]

, 2009
Background: The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments.
Frölich, Lutz, Gertz, Hermann-Josef, Hampel, Harald, Henn, Fritz, Heuser, Isabella, Huell, Michael, Jahn, Holger, Jessen, Frank, Kornhuber, Johannes, Luckhaus, Christian, Maier, Wolfgang, Pantel, Johannes, Perneczky, Robert, Peters, Oliver, Rienhoff, Otto, Ruüther, Eckart, Schmidtke, Klaus, Schroeder, Johannes, Seuchter, Susanne A., Weih, Markus, Wiltfang, Jens, Wolf, Stefanie   +21 more
core   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source

Biomimetic Analysis of Neurotransmitters for Disease Diagnosis through Light‐Driven Nanozyme Sensor Array and Machine Learning

Advanced Science, EarlyView.
A novel photoresponsive nanozyme sensor array, combining metal‐organic frameworks (MOFs) with advanced machine learning algorithms, provides a breakthrough in rapid neurotransmitter detection and disease diagnostics. This sensor array is capable of accurately identifying neurotransmitter profiles associated with neurological disorders, offering ...
Kun Yu, Siyuan Lu, Kaiwen Qiu, Yuanzun Zhang, Aobing Sun, Shiqi Gong, Kai Wang, Xuzhu Gao, Xiangyu Xu, Hao Wang   +9 more
wiley   +1 more source

Duration of Posttraumatic Amnesia Predicts Neuropsychological and Global Outcome in Complicated Mild Traumatic Brain Injury. [PDF]

, 2016
OBJECTIVES: Examine the effects of posttraumatic amnesia (PTA) duration on neuropsychological and global recovery from 1 to 6 months after complicated mild traumatic brain injury (cmTBI). PARTICIPANTS: A total of 330 persons with cmTBI defined as Glasgow
Barber, Jason, Diaz-Arrastia, Ramon, Dikmen, Sureyya S., Hart, Tessa, Hesdorffer, Dale C., Hsu, Nancy H., Jallo, Jack, Novack, Thomas A., Ricker, Joseph, Temkin, Nancy, Zafonte, Ross   +10 more
core   +2 more sources

Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes

Advanced Science, EarlyView.
Dynamic neural deactivation bridges traditionally distinct inhibitory mechanisms—direct inhibition and competition‐induced inhibition—revealing a common neural signature across modalities. Multimodal neuroimaging and behavioral experiments demonstrate a temporal dynamic characterized by progressive frontoparietal activation decay and enhanced sensory ...
Zhenhong He, Yifan Du, Ziqi Fu, Youcun Zheng, Nils Muhlert, Barbara Sahakian, Rebecca Elliott   +6 more
wiley   +1 more source

Saudi normative data for the Wisconsin Card Sorting Test, Stroop Test, Test of Non-verbal Intelligence-3, Picture Completion and Vocabulary (subtest of the Wechsler Adult Intelligence Scale-Revised). [PDF]

, 2011
There are 2 aims for this study: first, to collect normative data for the Wisconsin Card Sorting Test (WCST), Stroop test, Test of Non-verbal Intelligence (TONI-3), Picture Completion (PC) and Vocabulary (VOC) sub-test of the Wechsler Adult Intelligence ...
Al-Ghatani, A.M., Al-Moutaery, K.R., Binshaig, B.A., Obonsawin, M.C.   +3 more
core  

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

Ageism and Neuropsychological Tests [PDF]

, 2018
The performance of older adults on neuropsychological (and cognitive) assessment tests can set the perspective on the capabilities of this population in general, hence contributing to ageism. These tests are administered with two implicit assumptions: (a) the tests are a valid gauge of performance in older adults and (b) cognitive abilities decline in ...
Hadas Erel, Gali Malkin, Boaz M. Ben-David   +2 more
openaire   +2 more sources

The Behavioral Phenotype and Importance of Multidisciplinary Care in Patients With Sotos Syndrome: A Single‐Center Experience

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Sotos syndrome is an autosomal dominant condition caused by pathogenic variants in the NSD1 gene on chromosome 5q35. It is characterized by macrosomia, distinctive facial features, and developmental delays. Patients are also reported to have a behavioral phenotype including autism spectrum disorder, attention deficit/hyperactivity disorder ...
Aravind Viswanathan, Andrew M. George, Evan R. Hathaway, Carlyn Glatts, Jennifer M. Kalish   +4 more
wiley   +1 more source