Non-verbal episodic memory deficits in primary progressive aphasias are highly predictive of underlying amyloid pathology [PDF]
Diagnostic distinction of primary progressive aphasias (PPA) remains challenging, in particular for the logopenic (lvPPA) and nonfluent/agrammatic (naPPA) variants.
Ahmed+24 more
core +1 more source
Sex Differences in Associations of Lewy Body Disease with Alzheimer's Disease and Cognitive Decline
Objective To investigate how sex and age at menopause influence the interplay between Alzheimer's disease (AD) and Lewy body disease (LBD) neuropathologies, and their associations with cognitive decline. Methods We analyzed data from: (1) three Rush Alzheimer's Disease Center cohorts (i.e., the Religious Orders Study, Rush Memory and Aging Project, and
Madeline Wood Alexander+17 more
wiley +1 more source
Moderators, mediators and nonspecific predictors of outcome after cognitive rehabilitation of executive functions in a randomised controlled trial [PDF]
Moderators, mediators and nonspecific predictors of treatment after cognitive rehabilitation of executive functions in a randomised controlled trial Objective: To explore moderators, mediators and nonspecific predictors of executive functioning after ...
Evans, Jonathan+5 more
core +1 more source
Objective Blood‐based biomarkers for Alzheimer's disease (AD), representing antemortem indicators of AD pathophysiology, have greatly improved the accuracy of diagnosis. However, these biomarkers may not capture a frequent coincident pathology, such as cerebrovascular disease.
Tamil Iniyan Gunasekaran+12 more
wiley +1 more source
Investigating the 'latent' deficit hypothesis : age at time of head injury, executive and implicit functions and behavioral insight [PDF]
This study investigated the 'latent deficit' hypothesis in two groups of frontotemporal headinjured patients, those injured prior to steep morphological and corresponding functional maturational periods for frontotemporal networks (≤ age 25), and those ...
Andrade, Jackie+4 more
core +1 more source
Objective Socioeconomic status (SES) and lifestyle activities (LA) are strongly related, and both are associated with dementia risk. We investigated the influence of SES and LA on brain atrophy and cognitive decline considering amyloid‐beta (Aβ) positron emission tomography and white matter hyperintensity (WMH) load.
Dario Bachmann+11 more
wiley +1 more source
A comparison of magnetic resonance imaging and neuropsychological examination in the diagnostic distinction of Alzheimer’s disease and behavioral variant frontotemporal dementia [PDF]
The clinical distinction between Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) remains challenging and largely dependent on the experience of the clinician.
Andersson+43 more
core +1 more source
Persisting Transglutaminase 6 Antibodies in Neurological Gluten‐Related Disorders
Objective Gluten‐related autoimmunity can cause neurological disease, although the best way to diagnose and monitor such patients is unclear. Serological testing for antibodies against transglutaminase 6 (TG6) has been proposed; however, this is not widely available in clinical practice.
Iain D. Croall+6 more
wiley +1 more source
Altered hippocampal function in major depression despite intact structure and resting perfusion [PDF]
Background: Hippocampal volume reductions in major depression have been frequently reported. However, evidence for functional abnormalities in the same region in depression has been less clear.
A. Finkelmeyer+18 more
core +2 more sources
Objective In Parkinson's disease (PD), the power of beta oscillations (± 13–30 hertz [Hz]) from subthalamic nucleus (STN) local field potentials (LFPs) is associated with motor symptoms. Beta power can be used for adaptive deep brain stimulation (aDBS) algorithms based upon symptom fluctuations.
Martijn G.J. de Neeling+8 more
wiley +1 more source