Results 91 to 100 of about 36,163 (243)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

open access: yesEpilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang   +3 more
wiley   +1 more source

Redefining drug‐resistant epilepsy: Insights from an Italian Delphi consensus study

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects approximately one‐third of people with epilepsy (PwE) despite advancements in anti‐seizure medications and presents significant challenges in epilepsy care. This Delphi consensus study aimed to examine key aspects of DRE, including its definition, predictors, and therapeutic strategies. Methods A
Federico Vigevano   +4 more
wiley   +1 more source

Neuronal surface and intracellular antibody testing in patients with long‐term epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Objective We aimed to investigate the frequency of neuronal surface and intracellular antibodies in individuals with long‐term epilepsy and the associated clinical and laboratory characteristics. Methods We tested sera from 223 patients with epilepsy without signs of autoimmune encephalitis and 12 patients with epilepsy and a subacute onset of
Nancy Watanabe   +9 more
wiley   +1 more source

Ictal emotional features in pediatric and young adult patients with frontal lobe epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Objective To assess the localization and lateralization values of ictal emotional features and ictal defensive behaviors in pediatric and young adult patients with frontal lobe epilepsy (FLE). Methods Children and young adults with FLE were identified from a single institution's epilepsy surgery database.
Ming‐Chen Tsai   +6 more
wiley   +1 more source

Cognitive outcomes after deep brain stimulation in drug‐resistant epilepsy: A comparison of anterior thalamic and hippocampal stimulation

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Deep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) and hippocampus is an emerging therapy for drug‐resistant epilepsy (DRE) when resective surgery is not feasible. We aimed to evaluate the long‐term cognitive outcomes of these two DBS targets, hypothesizing that both interventions preserve cognitive function ...
Seonjeong Kim   +5 more
wiley   +1 more source

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