Results 91 to 100 of about 112,414 (193)

Deep Phenotyping of the Broader Autism Phenotype in Epilepsy: A Transdiagnostic Marker of Epilepsy and Autism Spectrum Disorder

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective We conducted deep and minimal phenotyping of the broader autism phenotype (BAP) in people with epilepsy (PWE) and compared its expression with published rates in the general population and relatives of individuals with autism spectrum disorder (ASD‐relatives).
Annie E. Richard, Ingrid E. Scheffer, Sarah J. Wilson   +2 more
wiley   +1 more source

Increased Serum Neurofilament Light Chain Concentration Associated With Microglial Morphology Changes in Chronically‐Starved Mice

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is associated with hyperactivity, amenorrhea, and brain atrophy. Weight rehabilitation reversed these symptoms, although the underlying pathophysiological mechanisms are mostly unknown. Serum neurofilament light chain (NfL) levels are widely used as a biomarker of neurodegeneration. Based on neuroimaging studies
Annelie Zimmermann, Hanna Rupprecht, Stephan Lang, Rickmer Wienecke, Hanna‐Sophia Henschke, Kaja Dickert, Katharina Schuster, Anna Staffeld, Christoph Berger, Alexander Dück, Michael Kölch, Antje Vogelgesang, Matthias Grothe, Leo Heinig, Lukas Wenzel, Markus Kipp, Linda Frintrop   +16 more
wiley   +1 more source

eBEfree: Combining Psychoeducation, Mindfulness, and Self‐Compassion in an App‐Based Psychological Intervention to Manage Binge‐Eating Symptoms: A Randomized Controlled Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To develop and test the effectiveness of the eBEfree program, a 12‐session app‐based version of a previously tested psychological intervention (BEfree) that combines psycho‐education, self‐compassion, mindfulness, and Acceptance and Commitment Therapy to reduce binge‐eating symptoms.
Hugo Senra, Cristiana Duarte, Sérgio A. Carvalho, Luís Simões, Cláudia Ferreira, Lara Palmeira, Marcela Matos, Marina Cunha, Paula Castilho, Bruno Sousa, Luis Cordeiro, José Pinto‐Gouveia   +11 more
wiley   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Nucleus accumbens shell electrical lesion attenuates seizures and gliosis in chronic temporal lobe epilepsy rats

Epileptic Disorders, Volume 27, Issue 2, Page 204-218, April 2025.
Abstract Objective Temporal lobe epilepsy (TLE) is the most prevalent form of epilepsy. Prior research has indicated the involvement of the nucleus accumbens shell (NAcSh) in the process of epileptogenesis, thereby implying its potential as a therapeutic target for TLE.
Shuaishuai Xue, Peiyao Yi, Yangqi Mao, Zhengming Zhan, Yonghua Cai, Zibin Song, Kewan Wang, Kaijun Yang, Ye Song, Xingqin Wang, Hao Long   +10 more
wiley   +1 more source

Effect of stereo‐EEG versus subdural EEG on functional and seizure outcome in pediatric and adult epilepsy surgery: A 21‐year single‐center experience

Epileptic Disorders, EarlyView.
Abstract Objective (1) To compare use, benefits, and complications of stereo‐EEG (SEEG) and subdural EEG (SD) in presurgical epilepsy candidates. (2) To evaluate the effectiveness of both methods in delineation of the epileptogenic zone (EZ) and guiding tailored resective surgery. Methods We included patients with SEEG or SD evaluations in children and
Ahmed Gaballa, Christian G. Bien, Philip Grewe, Anne Hagemann, Thilo Kalbhenn, Tilman Polster, Friedrich G. Woermann, Thomas Cloppenborg   +7 more
wiley   +1 more source

Reflex “toothbrushing” epilepsy: Seizure freedom after focal ablation assisted by ictal fMRI

Epileptic Disorders, EarlyView.
Abstract A 22‐year‐old female presented with drug‐resistant focal motor seizures with onset at age 14. This manifested as daily episodes of right facial dystonia triggered by toothbrushing, but also by eating, talking, and strenuous exercise. On ictal scalp EEG, there was low‐voltage fast activity over the left pericentral area.
Michael Ginevra, John Archer, Kristian Bulluss, Chris Tailby, Graeme D. Jackson, David N. Vaughan   +5 more
wiley   +1 more source

Features of cognitive dysfunction in late‐onset temporal lobe epilepsy

Epileptic Disorders, EarlyView.
Abstract Objective A global increase in the aging population has resulted in more patients with late‐onset epilepsy. Late‐onset temporal lobe epilepsy (LOTLE) is one of the most common types of late‐onset epilepsy and is frequently accompanied by memory impairments.
Naoya Hasegawa, Natsumi Saito, Masafumi Fukuda   +2 more
wiley   +1 more source

Continuing medical education in epileptology: The Level 1‐2‐3 experience of the ILAE academy

Epileptic Disorders, EarlyView.
Abstract The International League Against Epilepsy (ILAE) Academy is the world's eminent e‐learning campus for epileptology. Its modular teaching content was developed to cover all competencies and learning objectives specified in the ILAE's curriculum for epileptology.
Ingmar Blümcke, Eva Biesel, Samuel Wiebe, Sandor Beniczky, Jo M. Wilmshurst, Man Mohan Mehndiratta, Ali A. Asadi‐Pooya, Christian Brandt, Alexis Arzimanoglou, Gagandeep Singh, on behalf of the ILAE Academy content development faculty, Raidah Al Baradie, Carmen Barba, Jocelyn F. Bautista, Sallie Baxendale, Elena Belousova, Isabella Brambilla, Jorge G. Burneo, Leonor Cabral‐Lim, Jaime Carrizosa, Jaume Campistol, Hannah Cock, Marion Comajuan, Helen Cross, Emilija Cvetkovska, Valentina De Giorgis, Luca De Palma, Kirsten A. Donald, Georg Dorfmüller, Guadalupe Fernandez Baca Vaca, Jessica Fesler, Irene García Morales, Christina Giavasi, Maria Gogou, Patricia Gómez Iglesias, Samson Gwer, Till Hartlieb, Martin Holtkamp, Floor E. Jansen, Bosanka Jocic‐Jakubi, Philippe Kahane, Ioannis Karakis, Takafumi Kubota, Joshua Laing, Tatjana Liakina, Aileen McGonigal, Rosa Michaelis, Ioana Mindruta, Andrew Neal, Maureen Njoroge, Irina Oane, Terence O’Brien, Finbar O’Callaghan, Manuela Ochoa Urrea, Nicholas Odero, Sebastián Ortiz, Karine Ostrowsky‐Coste, Maria T. Papadopoulou, Tiziana Pisano, Anna Rada, Stefan Rampp, Markus Reuber, Sylvain Rheims, Andrea O. Rossetti, Guido Rubboli, Victoria San Antonio‐Arce, Jan‐Christoph Schoene‐Bake, Artem Sharkov, Hugh D. Simpson, Mary Lou Smith, Ana Suller Marti, Rainer Surges, Roland Thijs, Joseph Toulouse, Bart van den Munckhof, Bernd J. Vorderwülbecke, Alistair Wardrope, Peter Wolf, Elza Márcia Yacubian   +78 more
wiley   +1 more source

Creativity and its link to epilepsy

Epilepsia Open, EarlyView.
Abstract Creative thinking represents one of our highest‐order cognitive processes, involving multiple cortical structures and an intricate interplay between several cortical and subcortical networks. It results in novel ideas that translate to useful products or concepts. The evolutionary purpose of creativity is therefore apparent, as it advances our
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source