Results 101 to 110 of about 193,598 (342)

The degraded concept representation system in semantic dementia:damage to pan-modal hub, then visual spoke [PDF]

open access: yes, 2012
The core clinical feature of semantic dementia is a progressive yet selective degradation of conceptual knowledge. Understanding the cognitive and neuroanatomical basis for this deficit is a key challenge for both clinical and basic science.
Acosta-Cabronero   +88 more
core   +2 more sources

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

open access: yesAdvanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger   +17 more
wiley   +1 more source

Assessing the Relative Importance of Imaging and Serum Biomarkers in Capturing Disability, Cognitive Impairment, and Clinical Progression in Multiple Sclerosis

open access: yesAdvanced Science, EarlyView.
Using machine‐learning analyses in two independent multiple sclerosis cohorts, spinal cord atrophy and cortical degeneration emerged as key predictors of disability and progression independent of relapses. Deep gray matter damage further improved prediction, while serum biomarkers of brain damage provided complementary information, highlighting the ...
Alessandro Cagol   +17 more
wiley   +1 more source

A Perspective on the Potential Role of Neuroscience in the Court [PDF]

open access: yes, 2016
This Article presents some lessons learned while offering expert testimony on neuroscience in courts. As a biomedical investigator participating in cutting-edge research with clinical and mentoring responsibilities, Dr. Ruben Gur, Ph.D., became involved
Gur, Alon G.   +3 more
core   +1 more source

Automatic memory processes in normal ageing and Alzheimer’s disease [PDF]

open access: yes, 2008
This study examined the contribution of automatic and controlled uses of memory to stem completion in young, middle-aged and older adults, and compared these data with a study involving patients with Alzheimer’s disease (AD) who performed the same task ...
Adam   +49 more
core   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

open access: yesAdvanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh   +17 more
wiley   +1 more source

The role of neuropsychology in stereo‐EEG: A narrative review

open access: yesEpilepsia Open
Stereo‐EEG is accompanied by unique neuropsychological challenges in the workup, during the admission, and following the procedure. While established principles from epilepsy surgery programs provide a guiding framework for clinical practice, specialized
Emily Cockle   +5 more
doaj   +1 more source

Learning and discrimination through STDP in a top-down modulated associative memory

open access: yes, 2006
This article underlines the learning and discrimination capabilities of a model of associative memory based on artificial networks of spiking neurons.
Mouraud, Anthony, Paugam-Moisy, Hélène
core   +4 more sources

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