Results 71 to 80 of about 36,163 (243)
Factors Influencing the Duration From the Initiation of Surgical Evaluation to Final Intervention in Pediatric Epilepsy Surgery
Annals of the Child Neurology Society, EarlyView.ABSTRACT Rationale
Longer duration of epilepsy before surgery is a predictor of poor outcome. While referral delays of surgical candidates are well documented, factors causing delay during the presurgical evaluation remain unclear and may vary depending on institutional characteristics.Ruba Al‐Ramadhani, Ann Hyslop, Avery R. Caraway, Edward J. Novotny, Adam P. Ostendorf, Krista L. Eschbach, Allyson L. Alexander, Lily C. Wong‐Kisiel, Dewi F. Depositario‐Cabacar, Chima O. Oluigbo, Cemal Karakas, Samir R. Karia, Priyamvada Tatachar, Jeffrey Bolton, Pilar D. Pichon, Daniel W. Shrey, Erin Fedak Romanowski, Nancy A. McNamara, Ernesto Gonzalez‐Giraldo, Kurtis Auguste, Danilo Bernardo, Rani K. Singh, Pradeep K. Javarayee, Jenny J. Lin, Jason C. Coryell, Shilpa B. Reddy, Abhinaya Ganesh, Michael A. Ciliberto, Debopam Samanta, Kristen H. Arredondo, Ahmad Marashly, Zachary M. Grinspan, Dallas Armstrong, Taylor J. Abel, Janelle Wagner, Derryl J. Miller, Fernando N. Galan, Michael Scott Perry +37 morewiley +1 more sourceSafety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study
Clinical Pharmacology in Drug Development, EarlyView.Abstract
Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye +7 morewiley +1 more sourceConnecting the dots: A narrative review of the relationship between heart failure and cognitive impairment
ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.Abstract
Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti +6 morewiley +1 more sourcePrognostic impact of peak oxygen consumption in heart failure: A systematic review and meta‐analysis
ESC Heart Failure, EarlyView.Based on 64 studies, each 1 mL/kg/min increase in VO2peak significantly reduced all‐cause mortality (HR: 0.86, 95% CI 0.82–0.90) and combined outcomes of ventricular assist device, transplant and all‐cause mortality (HR: 0.84, 95% CI 0.79–0.89) in patients with heart failure, though no significant association was observed with cardiovascular mortality (Konstantinos Prokopidis, Krzysztof Irlik, Julia Piaśnik, Zuzanna Michalska, Mirela Hendel, Katarzyna Nabrdalik, Gregory Y.H. Lip +6 morewiley +1 more sourceContinuing medical education in epileptology: The Level 1‐2‐3 experience of the ILAE academy
Epileptic Disorders, EarlyView.Abstract
The International League Against Epilepsy (ILAE) Academy is the world's eminent e‐learning campus for epileptology. Its modular teaching content was developed to cover all competencies and learning objectives specified in the ILAE's curriculum for epileptology.Ingmar Blümcke, Eva Biesel, Samuel Wiebe, Sandor Beniczky, Jo M. Wilmshurst, Man Mohan Mehndiratta, Ali A. Asadi‐Pooya, Christian Brandt, Alexis Arzimanoglou, Gagandeep Singh, on behalf of the ILAE Academy content development faculty, Raidah Al Baradie, Carmen Barba, Jocelyn F. Bautista, Sallie Baxendale, Elena Belousova, Isabella Brambilla, Jorge G. Burneo, Leonor Cabral‐Lim, Jaime Carrizosa, Jaume Campistol, Hannah Cock, Marion Comajuan, Helen Cross, Emilija Cvetkovska, Valentina De Giorgis, Luca De Palma, Kirsten A. Donald, Georg Dorfmüller, Guadalupe Fernandez Baca Vaca, Jessica Fesler, Irene García Morales, Christina Giavasi, Maria Gogou, Patricia Gómez Iglesias, Samson Gwer, Till Hartlieb, Martin Holtkamp, Floor E. Jansen, Bosanka Jocic‐Jakubi, Philippe Kahane, Ioannis Karakis, Takafumi Kubota, Joshua Laing, Tatjana Liakina, Aileen McGonigal, Rosa Michaelis, Ioana Mindruta, Andrew Neal, Maureen Njoroge, Irina Oane, Terence O’Brien, Finbar O’Callaghan, Manuela Ochoa Urrea, Nicholas Odero, Sebastián Ortiz, Karine Ostrowsky‐Coste, Maria T. Papadopoulou, Tiziana Pisano, Anna Rada, Stefan Rampp, Markus Reuber, Sylvain Rheims, Andrea O. Rossetti, Guido Rubboli, Victoria San Antonio‐Arce, Jan‐Christoph Schoene‐Bake, Artem Sharkov, Hugh D. Simpson, Mary Lou Smith, Ana Suller Marti, Rainer Surges, Roland Thijs, Joseph Toulouse, Bart van den Munckhof, Bernd J. Vorderwülbecke, Alistair Wardrope, Peter Wolf, Elza Márcia Yacubian +78 morewiley +1 more sourceDiagnostic Challenges in the Neuropsychology of Epilepsy: Report of the ILAE Neuropsychology Task Force Diagnostic Methods Commission: 2021–2025
Epileptic Disorders, EarlyView.Abstract
Increasingly, it has been recognized that non‐seizure‐related factors influence how people with epilepsy perform on neuropsychological tests. Therefore, neuropsychologists need to recognize the constellation of factors that can contribute to the neurocognitive presentation of a person with epilepsy and consider these factors in the ...Mary Lou Smith, Mayu Fujikawa, Genevieve Rayner, Seth A. Margolis, Bruce Hermann, Gus Baker, Sallie Baxendale, Robyn Busch, Aimee Dollman, Vicki Ives‐Deliperi, Carrie R. McDonald, Urvashi Shah, Sarah Wilson +12 morewiley +1 more source