Results 91 to 100 of about 64,252 (237)
Quantitative Assessment of Visible Nigrosome‐1 in Patients with Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.Abstract Background
The nigrosome‐1 (N1) sign on susceptibility‐weighted imaging (SWI) typically disappears in Parkinson's disease (PD), though some patients can show uni−/bilaterally preserved N1. Objective
Investigating whether visible nigrosomes in PD patients differ from those of healthy subjects (HC). Methods
Forty‐eight PD and 35 HC underwent 3 T‐Maria Eugenia Caligiuri, Ilaria Chimento, Marida De Maria, Emma Biondetti, Jolanda Buonocore, Valerio Riccardo Aquila, Maria Celeste Bonacci, Emanuele Tinelli, Umberto Sabatini, Aldo Quattrone, Andrea Quattrone +10 morewiley +1 more sourceA Severity‐Agnostic Atrophy Pattern in Spinocerebellar Ataxia Type 3: Volumetrics from ENIGMA‐Ataxia
Movement Disorders, EarlyView.Background
Spinocerebellar ataxia type 3 (SCA3) is a rare, inherited neurodegenerative disease characterized by progressive loss of motor coordination. Objectives
We undertook a multisite magnetic resonance imaging study to profile the spatial spread of atrophy across the brain, determine whether atrophy preferentially maps onto specific functional ...Jason W. Robertson, Isaac Adanyeguh, David J. Arpin, Tetsuo Ashizawa, Benjamin Bender, Fernando Cendes, Xi Chen, Giulia Coarelli, Léo Coutinho, Andreas Deistung, Imis Dogan, Alexandra Durr, Jennifer Faber, for the ESMI MR Study Group, Juan Fernandez‐Ruiz, Mónica Ferreira, Marcondes C. França, Sophia L. Göricke, Shuo Han, Thomas Klockgether, Chen Liu, Jun Luo, Alberto R.M. Martinez, Sergio E. Ono, Chiadi U. Onyike, Gülin Öz, for the EUROSCA MR Study Group, Henry Paulson, Jerry L. Prince, Kathrin Reetz, Thiago J.R. Rezende, Matthis Synofzik, Hélio A. Ghizoni Teive, Sophia I. Thomopoulos, Paul M. Thompson, Dagmar Timmann, David Vaillancourt, Bart van de Warrenburg, Judith van Gaalen, Xingang Wang, Philipp Wegner, Sarah H. Ying, Ian H. Harding, Carlos R. Hernandez‐Castillo +43 morewiley +1 more sourcePlasma p‐tau217 Versus p‐tau181 in Parkinson's Disease: Differential Associations with Alzheimer's Disease‐Related Neurostructural Changes and Cognitive Function
Movement Disorders, EarlyView.Abstract Background
Plasma phosphorylated‐tau at threonine‐217 (p‐tau217) and threonine‐181 (p‐tau181) are scalable, minimally invasive biomarkers of Alzheimer's disease (AD) pathology. In Parkinson's disease (PD), AD co‐pathology may contribute to its clinical heterogeneity.Eleonora Fiorenzato, Simone Cauzzo, Giulia Musso, Roberta Biundo, Chiara Ceolin, Chiara Cosma, Carmelo Alessandro Fogliano, Wassilios G. Meissner, Valentina Misenti, Stefania Moz, Maria Laura Nasi, Francesca Vianello, Renzo Manara, Martina Montagnana, Giuseppe Sergi, Angelo Antonini, on behalf of the OPA Working Group +16 morewiley +1 more sourceHigh resolution and contrast 7 tesla MR brain imaging of the neonate
Frontiers in RadiologyIntroductionUltra-high field MR imaging offers marked gains in signal-to-noise ratio, spatial resolution, and contrast which translate to improved pathological and anatomical sensitivity.Philippa Bridgen, Philippa Bridgen, Raphael Tomi-Tricot, Raphael Tomi-Tricot, Raphael Tomi-Tricot, Raphael Tomi-Tricot, Alena Uus, Alena Uus, Daniel Cromb, Megan Quirke, Megan Quirke, Jennifer Almalbis, Jennifer Almalbis, Beya Bonse, Beya Bonse, Miguel De la Fuente Botella, Miguel De la Fuente Botella, Alessandra Maggioni, Alessandra Maggioni, Pierluigi Di Cio, Pierluigi Di Cio, Paul Cawley, Paul Cawley, Chiara Casella, Ayse Sila Dokumaci, Alice R. Thomson, Alice R. Thomson, Jucha Willers Moore, Jucha Willers Moore, Devi Bridglal, Joao Saravia, Thomas Finck, Anthony N. Price, Anthony N. Price, Elisabeth Pickles, Elisabeth Pickles, Elisabeth Pickles, Lucilio Cordero-Grande, Lucilio Cordero-Grande, Lucilio Cordero-Grande, Alexia Egloff, Alexia Egloff, Jonathan O’Muircheartaigh, Jonathan O’Muircheartaigh, Jonathan O’Muircheartaigh, Serena J. Counsell, Sharon L. Giles, Sharon L. Giles, Sharon L. Giles, Maria Deprez, Maria Deprez, Enrico De Vita, Enrico De Vita, Enrico De Vita, Enrico De Vita, Mary A. Rutherford, Mary A. Rutherford, Mary A. Rutherford, A. David Edwards, A. David Edwards, A. David Edwards, Joseph V. Hajnal, Joseph V. Hajnal, Joseph V. Hajnal, Shaihan J. Malik, Shaihan J. Malik, Shaihan J. Malik, Tomoki Arichi, Tomoki Arichi, Tomoki Arichi +69 moredoaj +1 more sourceGene Therapy for Amino Acid Decarboxylase Deficiency: Clinical and Imaging Outcomes in a French Cohort
Movement Disorders, EarlyView.Abstract Background
Intracerebral gene therapy is effective for amino acid decarboxylase (AADC) deficiency, but relationships between anatomical putaminal coverage, metabolic dynamics, and clinical recovery remain poorly understood. Objectives
Assess safety, long‐term efficacy, and clinical–radiological correlations in a genetically diverse European ...Clément Dunoyer, Gaëtan Poulen, Marie‐Céline François‐Heude, Eline Chauvet‐Piat, Bérénice Lecardonnel, Emmanuel Roze, Marie‐Ange Nguyen Morel, Domitille Gras, Adeline Quintard, Gaelle Baroux, Pierre Meyer, Philippe Coubes, Christophe Milesi, Julien Baleine, Chrystelle Sola, Vivien Szabo, Bénédicte Delye, Jana Haberlova, Mohamed Osman Eltahir Babiker, Mohammed Al Muqbil, Stéphanie Sanchez, Souad Touati, Nicolas Leboucq, Virginie Kouyoumdjian, Sylvia Sanquer, Denis Mariano‐Goulart, Thomas Roujeau, Agathe Roubertie +27 morewiley +1 more sourceKey Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review
Movement Disorders, EarlyView.Abstract
Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.Dorota Sarwinska, Maresa Buchholz, Audrey Iskandar, Marcus Grobe‐Einsler, Thomas Klockgether, Jennifer Faber, Bernhard Michalowsky +6 morewiley +1 more sourceView Order With Arbitrary Center Echoes
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose
To provide explicit, vendor‐independent view‐order constructions that enable selection of an arbitrary center echo in multi‐shot imaging, with a focus on RARE and MPRAGE. Methods
Vendor‐independent view‐order methods were developed to assign echo and shot indices to a prescribed set of phase encodes, enabling explicit selection of the ...Henric Rydén, Ola Norbeck, Sophie Schauman, Mikael Skorpil, Adam van Niekerk +4 morewiley +1 more sourceFree‐Breathing Hepatic Oxygen Extraction Fraction (OEF) Mapping Using Radial GESSE
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose
Noninvasive assessment of hepatic oxygenation is relevant for evaluating liver both in acute and long‐term liver pathologies. However, existing methods are limited to single‐slice acquisitions and require breath‐holding. This study aims to develop and evaluate a motion‐robust technique for whole‐liver oxygen extraction fraction (OEF ...Ke Zhang, Simon M. F. Triphan, Felix T. Kurz, Congcong Fu, Na Zhang, Christian H. Ziener, Mark E. Ladd, Heinz‐Peter Schlemmer, Hans‐Ulrich Kauczor, Oliver Sedlaczek +9 morewiley +1 more source