Results 91 to 100 of about 82,285 (244)

Altered Brain Structure in an ATRX‐Deficient Mouse Model of Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Mutations in the ATRX gene are a primary cause of alpha‐thalassemia intellectual disability X‐linked (ATRX) syndrome, which is characterized by intellectual disability, autism, and a range of brain structural abnormalities, including microcephaly.
Katherine Quesnel, Jacob Ellegood, Jason P. Lerch, Nathalie G. Bérubé   +3 more
wiley   +1 more source

Receptive–Expressive Language Phenotypes in Infants and Toddlers With Autism Features

Autism Research, EarlyView.
ABSTRACT Children diagnosed with autism often present with an atypical discrepancy between their receptive and expressive language levels, or an atypical receptive–expressive language phenotype. Children with an atypical receptive–expressive phenotype present with a relative receptive language advantage (expressive level < receptive level) or a ...
Torrey Cohenour, Amanda Gulsrud, Connie Kasari   +2 more
wiley   +1 more source

CRF binding protein activity in the hypothalamic paraventricular nucleus is essential for stress adaptations and normal maternal behaviour in lactating rats

Neurobiology of Stress
To ensure the unrestricted expression of maternal behaviour peripartum, activity of the corticotropin-releasing factor (CRF) system needs to be minimised.
Alice Sanson, Paula Krieg, Milena M. Schramm, Kerstin Kellner, Rodrigue Maloumby, Stefanie M. Klampfl, Paula J. Brunton, Oliver J. Bosch   +7 more
doaj   +1 more source

Towards a Developmental Retribution and Reciprocity Model (RRM): Implications for Youth Justice

Behavioral Sciences &the Law, EarlyView.
ABSTRACT Youth justice systems are frequently justified by reference to developmental change, yet chronological age is often treated as a proxy for underlying psychological processes. This paper develops a Developmental Retribution and Reciprocity Model (RRM), integrating evolutionary criminology with contemporary developmental neuroscience to clarify ...
Evelyn Svingen
wiley   +1 more source

Structural and Functional Imaging of Motor Outcomes in Twins With Perinatal Stroke: A Case Report

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Background Perinatal arterial ischemic stroke (AIS) affects 1 in 4000 live births. Dystonia, affecting ~20% of children following AIS, is characterized by involuntary muscle contractions and abnormal movements. Why some develop dystonia post AIS, while others do not, remains unclear.
Prisca Hsu, Trish Domi, Cecilia Jobst, Min Sheng, Amanda Robertson, Erum Syed, Pradeep Krishnan, Douglas Cheyne, Nomazulu Dlamini   +8 more
wiley   +1 more source

Learning the Lessons of Premature Discontinuation of Eating Disorder Therapy: Informing Guidelines to Improve Retention

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Around one to two in five patients prematurely disengage from eating disorder therapy. This Forum paper suggests innovative strategies to increase retention and strategies for evaluating these with patients who have eating disorders.
Tracey D. Wade, Ulrike Schmidt
wiley   +1 more source

Preclinical signal for a disease‐modifying effect on seizure cluster severity with intermittent diazepam treatment

Epilepsia, EarlyView.
Abstract Objective In epilepsy, daily treatment provides only symptomatic seizure control, leaving a significant unmet need for a treatment that affects the underlying predisposition to seizures. Here, in a first‐of‐its‐kind study, we test the hypothesis that intermittent treatment of seizure clusters with diazepam in the kainic acid post‐status ...
Qian Wu, Michelle Guignet, Jonathan Vuong, H. Steve White, Wesley T. Kerr, Evelyn K. Shih, Leock Y. Ngo, Enrique Carrazana, Adrian L. Rabinowicz   +8 more
wiley   +1 more source

Syndrome‐specific and familial imaging traits in juvenile absence epilepsy

Epilepsia, EarlyView.
Abstract Objective Juvenile absence epilepsy (JAE) is an idiopathic generalized epilepsy characterized by absences, generalized tonic–clonic seizures, and cognitive difficulties. In contrast to juvenile myoclonic epilepsy (JME), where distinct functional and structural brain alterations are well established, it remains unclear whether comparable ...
Fenglai Xiao, Lorenzo Caciagli, Luisa Delazer, Sjoerd Vos, Karin Trimmel, Louis Andre Van Graan, Marine Fleury, Lawrence Binding, Davide Giampiccolo, Dominic Heaney, Sanjeev Rajakulendran, Maria Centeno, Josemir W. Sander, John S. Duncan, Matthias J. Koepp, Britta Wandschneider   +15 more
wiley   +1 more source

Is posttraumatic stress disorder specific to drug‐resistant epilepsy or a common feature of chronic disease? A comparative study with atrial fibrillation and type 1 diabetes

Epilepsia, EarlyView.
Abstract Objective Posttraumatic stress disorder (PTSD) is more prevalent in epilepsy than in the general population. However, it remains unclear whether this association is specific to epilepsy or a broader consequence of experiencing unpredictable acute episodes within chronic diseases.
Lisa‐Dounia Soncin, Capucine Rodet, Mina Aboulmakarim, Bernard Giusiano, Marie Arthuis, Jean‐Claude Deharo, Patrice Darmon, Olivia Ronsin, Sylvane Faure, Fabrice Bartolomei   +9 more
wiley   +1 more source

Cellular quiescence uncouples the proteome from the transcriptome in neural stem cells

The EMBO Journal
Quiescence is a cellular state defined by reversible cell-cycle arrest and diminished biosynthesis, particularly of nucleic acids and proteins. These features protect stem cells from proliferation-induced mutations, self-renewal exhaustion, and ...
Alice Rossi, Antoine Coum, Manon Madelenat, Lachlan Harris, Stephanie Strohbuecker, Andrea Chai, Hania Fiaz, Rita Chaouni, Peter Faull, Neve Costello Heaven, William Grey, Dominique Bonnet, Fursham Hamid, Eugene V Makeyev, Ambrosius P Snijders, Gavin Kelly, François Guillemot, Rita Sousa-Nunes   +17 more
doaj   +1 more source