Results 61 to 70 of about 82,285 (244)

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality

eLife
Contextual fear conditioning (CFC) is a classical laboratory task that tests associative memory formation and recall. Techniques such as multi-photon microscopy and holographic stimulation offer tremendous opportunities to understand the neural ...
Seetha Krishnan, Can Dong, Heather Ratigan, Denisse Morales-Rodriguez, Chery Cherian, Mark Sheffield   +5 more
doaj   +1 more source

Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface

Advanced Science, EarlyView.
Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley   +1 more source

Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum

Nature Communications
Non-synaptic (intrinsic) plasticity of membrane excitability contributes to aspects of memory formation, but it remains unclear whether it merely facilitates synaptic long-term potentiation or plays a permissive role in determining the impact of synaptic
Ting-Feng Lin, Silas E. Busch, Christian Hansel   +2 more
doaj   +1 more source

Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling

Nature Communications, 2019
The authors use a forward genetic screen to discover postsynaptic factors required for homeostatic synaptic plasticity at the Drosophila neuromuscular junction. They identify insomniac and the ubiquitin ligase Cul3, genes involved in sleep regulation, to
Koto Kikuma, Xiling Li, Sarah Perry, Qiuling Li, Pragya Goel, Catherine Chen, Daniel Kim, Nicholas Stavropoulos, Dion Dickman   +8 more
doaj   +1 more source

BRAIN IMAGING VS. COMPUTATIONAL IMAGING: INTEGRATING NEUROSCIENCE INTO THE DIGITIZATION OF EDUCATION [PDF]

Analele Universităţii din Craiova. Psihologie, Pedagogie
The alliance between neuroscience and education promotes better analysis of the learning process and enriching teaching practices to make it more dynamic and effective.
Euphrosyne EFTHIMIADOU
doaj   +1 more source

Advancing Precision Nutrition Through Multimodal Data and Artificial Intelligence

Advanced Science, EarlyView.
Individual responses to food vary dramatically, challenging traditional dietary advice. This review explores how the unique genetic makeup, gut microbiome, and brain activity shape host metabolic health. We examine how artificial intelligence integrates these multimodal data to predict individualized dietary needs, moving beyond one‐size‐fits‐all ...
Yuanqing Fu, Ke Zhang, Zelei Miao, Gaoyi Yang, Yujing Huang, Ju‐Sheng Zheng   +5 more
wiley   +1 more source

Leveraging neuroscience education to address stigma related to opioid use disorder in the community: a pilot study

Frontiers in Psychiatry
Opioid use disorder (OUD) and overdose deaths are a public health crisis. One contributing factor is stigma towards people who use opioids. We developed and conducted a public-facing, half-day educational event designed to challenge misperceptions about ...
Evan J. Kyzar, Melissa R. Arbuckle, Adam Abba-Aji, Krishna Balachandra, Joseph Cooper, Adriane Dela Cruz, Ellen Edens, Brady Heward, Brady Heward, Michael Jibson, Ayana Jordan, Daniel Moreno-De-Luca, Daniel Moreno-De-Luca, Hannah Pazderka, Mohit Singh, Jeremy J. Weleff, Jeremy J. Weleff, Bernice Yau, Justin Young, David A. Ross   +19 more
doaj   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Music and neuroscience: a multidisciplinary approach to the neurobiological substrates of music related behavior [PDF]

Annals of General Psychiatry, 2006
Two decades ago, the idea to focus on music-related aspects of behaviour as a methodological tool to study the neural correlates of human complex cognitive functions was a rather uncommon practice within neuroscience. Nowadays, a rapidly evolving field has been formed under the general name "The Neuroscience of Music" as an attempt to develop a whole ...
openaire   +2 more sources