Results 41 to 50 of about 676,596 (342)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Choosing Neuroanaesthesia as a career: Marching towards new horizons

Indian Journal of Anaesthesia, 2021
Anaesthesiology is an ever-changing science and amongst its sub-specialities, the field of neuroanaesthesia is making rapid strides. The fragility of the brain and spinal cord and the multitude of complexities involved in neurosurgery and interventional ...
Ankur Khandelwal, Kiran Jangra, Manisha D Katikar, Padmaja Durga, G S. Uma Maheswara Rao   +4 more
doaj   +1 more source

Consciousness And Self-Identity: A Phenomenological View on a Cognitive Issue [PDF]

, 2011
The paper aims at analyzing the inner development of self-identity from its pre-reflective level to the full awareness one. The recent findings of neurosciences and cognitive studies suggest focusing attention on the complex relation between self as ...
Zippel, Nicola
core   +1 more source

Editorial: Topological Neuroscience [PDF]

Network Neuroscience, 2019
Topology, in its many forms, describes relations. It has thus long been a central concept in neuroscience, capturing structural and functional aspects of the organization of the nervous system and their links to cognition. Recent advances in computational topology have extended the breadth and depth of topological descriptions.
Expert, Paul, Lord, Louis David, Kringelbach, Morten L., Petri, Giovanni   +3 more
openaire   +4 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Making Room for Every Voice: Reimagining Person‐Centred Care in the Neurosciences

Health Expectations
Background This Special Issue of Health Expectations brings together 38 articles that exemplify the growing commitment to person‐centred care in the neurosciences. Moving beyond a historically brain‐centric model, these contributions reflect a more human
Miguel Toribio‐Mateas, Gareth Noble
doaj   +1 more source

Psicanálise e neurociências: um mapa dos debates Psicoanálisis y neurociencias: un mapa de los debates Psychoanalysis and neurosciences: a map of the debates

Psicologia em Estudo, 2010
Este artigo pretende apresentar um mapa panorâmico dos debates em torno da relação e da possível articulação entre a psicanálise e as neurociências. No campo psicanalítico são identificados três grupos principais, definidos a partir de seus pressupostos:
Marcia Moraes Davidovich, Monah Winograd
doaj   +1 more source

Language acquisition and speech rhythm patterns: an auditory neuroscience perspective

Royal Society Open Science, 2022
All human infants acquire language, but their brains do not know which language/s to prepare for. This observation suggests that there are fundamental components of the speech signal that contribute to building a language system, and fundamental neural ...
Usha Goswami
doaj   +1 more source