Results 81 to 90 of about 788,466 (338)

Practice Recommendations for Genetic Testing of Ataxias

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan   +7 more
wiley   +1 more source

Cognitive Impairment in Multiple Sclerosis: The Role of Clinical and Sociodemographic Factors ‐ A Systematic Review and Meta‐Analysis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment (CI) affects the quality of life in multiple sclerosis (MS). Identifying influencing factors is key to improving CI monitoring. This systematic review and meta‐analysis examines clinical and sociodemographic variables impacting the cognitive screening Symbol Digit Modalities Test (SDMT) performance across MS ...
Katalin Lugosi   +8 more
wiley   +1 more source

Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson\u27s disease. [PDF]

open access: yes, 2018
BACKGROUND: Parkinson\u27s disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relatively spared.
Cai, Jingli   +2 more
core   +1 more source

Gain modulation of synaptic inputs by network state in auditory cortex in vivo [PDF]

open access: yes, 2015
The cortical network recurrent circuitry generates spontaneous activity organized into Up (active) and Down (quiescent) states during slow-wave sleep or anesthesia.
Destexhe, Alain   +4 more
core   +3 more sources

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao   +10 more
wiley   +1 more source

Enjeux, difficultés et modalités de l’expression sur le travail : point de vue de la clinique médicale du travail

open access: yesPerspectives Interdisciplinaires sur le Travail et la Santé, 2012
Regardless of the job sector or hierarchical position, work intensification forces workers to make hard choices between the different goals they are expected to meet. Due to a lack of discussion, people have to manage by themselves.
Philippe Davezies
doaj   +1 more source

Neurofeminism and feminist neurosciences: a critical review of contemporary brain research

open access: yesFrontiers in Human Neuroscience, 2014
To date, feminist approaches to neurosciences have evaluated the debates surrounding practices of knowledge production within and research results of contemporary brain research.
S. Schmitz, Grit Höppner
semanticscholar   +1 more source

Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski   +13 more
wiley   +1 more source

The 100 Most Cited Papers Concerning the Insular Cortex of the Brain: A Bibliometric Analysis

open access: yesFrontiers in Human Neuroscience, 2018
Background: The insula is one of the most researched brain regions with many highly cited papers. However, unlike the literature of other fields, there is currently no study that has identified the 100 most cited papers within the literature of the ...
Andy W. K. Yeung
doaj   +1 more source

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