Results 151 to 160 of about 568,845 (390)

Low YTHDC1 Expression Upregulates FSCN1 to Promote Nuclear F‐Actin Formation and Facilitate Double‐strand DNA Breaks Repair in TMZ‐Resistant Glioblastoma

Advanced Science, EarlyView.
This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang, Wanxiang Niu, Yuanfei Wang, Peng Chen, Maolin Mu, Xiaoming Zhang, Ben Xu, Shanshan Hu, Chaoshi Niu, Pengfei Wu   +9 more
wiley   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Perspectives in Neurosurgery: Neurosurgery in Greece [PDF]

Neurosurgery, 1994
K S, Polyzoidis, A, Karavelis
openaire   +2 more sources

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Bibliometric Analysis of Neurosurgery Education From 1962 to 2023 [PDF]

Iranian Journal of Neurosurgery
Background and Aim: Evaluating our scientific trend and patterns in the education of neurosurgery can benefit in determining the needs and the future of the research path, therefore we performed a bibliometric analysis in the Web of Science (WoS) dataset.
Mansour Deylami, Maryam Ziyaei, Roohie Farzaneh, Fateme Maleki, Amin Dalili , Mehrdad Sayadinia, Tayyebeh Zarei , Navid Kalani   +7 more
doaj  

International Journal of Neurosurgery

, 2023

openalex   +1 more source

Association between physician characteristics and payments from industry in 2015-2017: observational study. [PDF]

, 2019
OBJECTIVE:To investigate the association between physician characteristics and the value of industry payments. DESIGN:Observational study. SETTING AND PARTICIPANTS:Using the 2015-2017 Open Payments reports of industry payments linked to the Physician ...
Blumenthal, Daniel M, Elashoff, David, Inoue, Kosuke, Tsugawa, Yusuke   +3 more
core  

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Machine Learning Based Prediction of Emergency Neurosurgery within 24 hours after Moderate to Severe Traumatic Brain Injury

, 2022
Jean-Denis Moyer, Patrick Lee, Charles Bernard, Lois Henry, Elodie Lang, Fabrice Cook, Fanny Planquart, Mathieu Boutonnet, Anatole Harrois, Tobias Gauss, Traumabase Group   +10 more
openalex   +1 more source

Correction to: Brain tissue segmentation in neurosurgery: a systematic analysis for quantitative tractography approaches [PDF]

, 2023
Puranam Revanth Kumar, Rajesh Kumar Jha, Amogh Katti   +2 more
openalex   +1 more source