Results 101 to 110 of about 8,861 (229)

Predictive markers of hemorrhagic transformation in ischemic stroke

Клиническая практика
Ischemic stroke remains a major medical, social, and economic concern due to high disability rates and substantial treatment and rehabilitation costs. Reperfusion therapy (thrombolysis and thrombectomy) is one of the most effective therapeutic options ...
Olga V. Lyang, Mikhail A. Soldatov, Leonid V. Klimov, Lesya B. Zavaliy, Tatiana V. Kiseleva, Daria N. Shamalova, Ilya L. Gubskiy, Nataliya A. Marskaya, Nikolay A. Shamalov   +8 more
doaj   +1 more source

Continuous Apomorphine Infusion in Multiple System Atrophy Real‐World Insights From a French Nationwide Retrospective Cohort

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Continuous subcutaneous apomorphine infusion (CSAI) is effective in Parkinson's disease but has not been evaluated in multiple system atrophy (MSA). Objective To assess the 6‐month efficacy and tolerability of CSAI in MSA patients. Methods French multicenter retrospective registry‐based analysis of CSAI use in MSA.
Simon Lamy, Frederique Leh, Alexandra Foubert‐Samier, Soizic Leguy Bonnet, Guillaume Baille, Margherita Fabbri, Margaux Dunoyer, Lise Mantisi, Caroline Giordana, Anaïs El Ouartassi, Olivier Rascol, Wassilios G. Meissner, David Bendetowicz, Marie Vanel, David Grabli, Fabienne Ory‐Magne, Sophie Drapier   +16 more
wiley   +1 more source

Experimental digital atlas of blood supply zones of the internal carotid artery

Клиническая практика
Background: The compilation of a neuroanatomic atlas based on a large sample is essentially a fundamental research work, but compiling a digital atlas during the epoch of wide usage of radiodiagnostics methods in the clinical and experimental practice ...
Ilya L. Gubskiy, Daria D. Namestnikova, Elvira A. Cherkashova, Ivan S. Gumin, Leonid V. Gubsky, Vladimir P. Baklaushev, Vladimir P. Chekhonin, Konstantin N. Yarygin   +7 more
doaj   +1 more source

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. Objectives To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to identify clinical variables associated with therapeutic response ...
Daniel Weiss, Idil Cebi, Marion Schütt, Imma Fischer, Lukas Pavelka, Pierre Kolber, Monika Pötter‐Nerger, Wolfgang Hamel, Andrea A. Kühn, Christian J. Hartmann, Kai Bötzel, Thomas Köglsperger, Michael T. Barbe, Zacharias Kohl, Steffen Paschen, Markus A. Hobert, Sergiu Groppa, Tobias Warnecke, Inga Claus, Rejko Krüger, Alireza Gharabaghi, For the Multicenter STN+SNr Study Group, Christian Stallinger, Frank Hertel, Daniel Kroneberg, Carsten Buhmann, Alessandro Gulberti, Beate Schönewald, Verena Zentsch, Verle Visser‐Vandewalle   +29 more
wiley   +1 more source

Challenges of Pain in Parkinson's Disease: Results from the OCEAN Study

Movement Disorders, EarlyView.
Abstract Background Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.
Kallol Ray Chaudhuri, Joaquim J. Ferreira, Angelo Antonini, Olivier Rascol, Monica M. Kurtis, Alexander Storch, José‐Francisco Rocha, Raquel Costa, Diogo Magalhães, Guillermo Castilla‐Fernández, Helena C. Brigas, Joerg Holenz, Per Odin, on behalf of the OCEAN study group   +13 more
wiley   +1 more source

Cerebellar Venous Infarction Combined with Developmental Venous Anomaly and Contralateral Sinus Thrombosis

Вестник рентгенологии и радиологии
Developmental venous anomalies (DVA) are among the most common malformations, accounting for about 55% of all cerebral vascular anomalies. Most of them are asymptomatic, detected incidentally by brain magnetic resonance imaging and do not require ...
A. P. Demyanov, M. B. Dolgushin, T. M. Rostovtseva   +2 more
doaj   +1 more source

Plasma p‐tau217 Versus p‐tau181 in Parkinson's Disease: Differential Associations with Alzheimer's Disease‐Related Neurostructural Changes and Cognitive Function

Movement Disorders, EarlyView.
Abstract Background Plasma phosphorylated‐tau at threonine‐217 (p‐tau217) and threonine‐181 (p‐tau181) are scalable, minimally invasive biomarkers of Alzheimer's disease (AD) pathology. In Parkinson's disease (PD), AD co‐pathology may contribute to its clinical heterogeneity.
Eleonora Fiorenzato, Simone Cauzzo, Giulia Musso, Roberta Biundo, Chiara Ceolin, Chiara Cosma, Carmelo Alessandro Fogliano, Wassilios G. Meissner, Valentina Misenti, Stefania Moz, Maria Laura Nasi, Francesca Vianello, Renzo Manara, Martina Montagnana, Giuseppe Sergi, Angelo Antonini, on behalf of the OPA Working Group   +16 more
wiley   +1 more source

Post‐Trial Responsibilities for Participants Implanted With Neurosurgical Devices: A Qualitative Study

Bioethics, EarlyView.
ABSTRACT The issue of post‐trial responsibility is about what is owed to research participants after a clinical trial ends, who is responsible, and how long this responsibility must endure. Despite two decades of international guidance on this issue, research involving novel high‐risk interventions—such as implantable neurotechnologies—raises ...
Nathan Higgins, Adrian Carter, John Gardner   +2 more
wiley   +1 more source

Organizing the laboratory testing procedures in ischemic stroke patients

Клиническая практика
Background: Arranging the laboratory tests for the patients presenting with suspected ischemic stroke, represents an important task for medical organizations.
Olga V. Lyang, Yulia V. Novozhenova, Irina A. Zhirova   +2 more
doaj   +1 more source

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source