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Role of neurotrophic factors in depression
Current Opinion in Pharmacology, 2007Major depression is associated with reduced volumes in the hippocampus and prefrontal cortex, whereas antidepressant treatments promote several forms of neuronal plasticity, including neurogenesis, synaptogenesis and neuronal maturation, in the hippocampus. Several neurotrophic factors are associated with depression or antidepressant action.
Vootele Voikar +2 more
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Neurotrophic Factors in Neuromuscular Disease
Physical Medicine and Rehabilitation Clinics of North America, 2005Neurotrophic factors (NTFs) are small dimeric proteins essential for development, function, maintenance, and plasticity of the vertebrate nervous system [1]. NTFs include glial-derived neurotrophic factor (GDNF), insulin-like growth factor 1 and 2 (IGF-1/2), ciliary neurotrophic factor (CNTF), vascular endothelial growth factor (VEGF) and the ...
Michael D. Weiss, B. Jane Distad
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Seminars in Neuroscience, 1995
Abstract During development, nerve growth factor (NGF) is a target-derived survival factor for neurones of the peripheral nervous system. Very recently, NGF has been found to have novel physiological roles in adult animals. In particular, I will review here the evidence that NGF is a crucial molecule in the neurobiology of pain. In the last few years
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Abstract During development, nerve growth factor (NGF) is a target-derived survival factor for neurones of the peripheral nervous system. Very recently, NGF has been found to have novel physiological roles in adult animals. In particular, I will review here the evidence that NGF is a crucial molecule in the neurobiology of pain. In the last few years
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Ciliary neurotrophic factor as an injury factor
Current Opinion in Neurobiology, 1993This article reviews recent evidence suggesting that endogenous ciliary neurotrophic factor may be involved in neural responses to injury, and discusses the possibility that ciliary neurotrophic factor could have therapeutic applications in a clinical setting.
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The Receptor for Ciliary Neurotrophic Factor
Science, 1991Although neurotrophic factors were originally isolated on the basis of their ability to support the survival of neurons, these molecules are now thought to influence many aspects of the development and maintenance of the nervous system. Identifying the receptors for these neurotrophic factors should aid in identifying the cells on which these factors ...
Samuel Davis +6 more
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Fast actions of neurotrophic factors
Current Opinion in Neurobiology, 1996A diversity of neurotrophic factors are required for the differentiation and survival of neurons and for maintaining their phenotype. By virtue of the rapid time scale of signal transduction in the cytosol, many of these factors also acutely regulate neuronal functions as diverse as synaptic transmission and nerve growth.
Mu-ming Poo, Benedikt Berninger
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1999
Preclinical and clinical data suggest that subcutaneous or intravenous administration of neurotrophic factors may be effective for the treatment of peripheral nervous system diseases. However, even though these proteins are natural products, they do present specific problems when used as therapeutic agents. They cannot be given by the oral route.
S. Pollack +4 more
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Preclinical and clinical data suggest that subcutaneous or intravenous administration of neurotrophic factors may be effective for the treatment of peripheral nervous system diseases. However, even though these proteins are natural products, they do present specific problems when used as therapeutic agents. They cannot be given by the oral route.
S. Pollack +4 more
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Role of neurotrophic factors in development
Trends in Genetics, 1988Abstract Neurotrophic factors are molecules which promote and regulate neuronal survival in the developing nervous system. They are distinguished from ubiquitous metabolites necessary for cellular maintenance and growth by their specificity: each neurotrophic factor promotes the survival of only certain kinds of neurons during a particular stage of ...
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Neurotrophic factors and Alzheimer's disease
Neurobiology of Aging, 1989Defects in essential trophic interactions represent one possible explanation for the systems degenerations that occur in Alzheimer's as well as other neurodegenerative diseases. Since a multiplicity of neural pathways are affected in Alzheimer's disease, it is likely that more than one neurotrophic factor may be implicated. Through modern approaches in
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