Results 241 to 250 of about 779,578 (304)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Neutral Buoyancy as a Simple Approach to Simulated Microgravity. [PDF]

Tissue Eng Regen Med
Kim HY, Kang S, Oh SH.
europepmc   +1 more source

Janus Photonic Graphics by Stratified Assembly of Two Distinct Colloids

Advanced Functional Materials, EarlyView.
Double‐sided Janus photonic micropatterns with vivid structural colors are fabricated through a single‐step bottom‐up strategy. Density‐driven stratification and depletion‐mediated crystallization of PMMA and PS binary colloids lead to exclusive lattices on opposite surfaces under centrifugal force.
Young Geon Kim, Yongseok Jung, Sehee Yang, Jiwoo Lee, Shin‐Hyun Kim   +4 more
wiley   +1 more source

Rapid subsurface warming in the subpolar North Atlantic from freshening. [PDF]

Nat Commun
Menviel LC, Pontes G, Lapeze M, Saini H.
europepmc   +1 more source

Controlled Engineering of 2D Alkali‐Iron‐Chloride Compounds and Lateral Quantum Heterostructures Within Confined Graphene Nanoreactors

Advanced Functional Materials, EarlyView.
This work presents a programmable atomic engineering strategy for 2D materials using Å‐scale nanoreactors formed by bilayer graphene (BLG) intercalation. A new class of alkali‐iron‐chloride compounds, along with lateral heterostructures composed of monolayer alkali halides and iron chlorides, is revealed.
Haiming Sun, Qiunan Liu, Yung‐Chang Lin, Mahdi Ghorbani‐Asl, Hiroki Ago, Arkady V. Krasheninnikov, Kazu Suenaga   +6 more
wiley   +1 more source

A Survey of Current Operations-Ready Thermospheric Density Models for Drag Modeling in LEO Operations. [PDF]

J Astronaut Sci
Mutschler S, Pilinski M, Bruinsma S, Sutton E, Tobiska WK, Knipp D, Fang TW, Casali S, Mallik V, DiLorenzo B, Siemes C.   +10 more
europepmc   +1 more source

Reduced Graphene Oxide Transparent Electrodes Enabling Compact Soft Tunable Lenses

Advanced Functional Materials, EarlyView.
By spray‐coating an elastomeric membrane with reduced graphene oxide (rGO) at various surface densities, elastomeric actuators are manufactured. Electro‐mechano‐optical characterizations show the suitability of rGO as an effective material for compliant, semi‐transparent electrodes, enabling soft electrically tunable lenses with a compact form factor ...
Giacomo Sasso, Alec Lamoreux, Nicola Pugno, James J. C. Busfield, Federico Carpi   +4 more
wiley   +1 more source

Effect of Polymer Structure on the Thermodynamics of Polyelectrolyte Complex Micelle Formation. [PDF]

Macromolecules
Dharmaraj VL, Fang Y, Tirrell MV.
europepmc   +1 more source

Intercepting Photogenerated Aminyl Radicals at Metal-Halide Perovskite Microcrystals to Forge C─N Bonds With Non-Preactivated Substrates. [PDF]

Small Sci
Conelli D, Margiotta N, Suranna GP, Grisorio R.   +3 more
europepmc   +1 more source

Imaging quantum chemistry in action with quantum attomicroscopy. [PDF]

Commun Chem
Golubev NV, Hassan MT.
europepmc   +1 more source