Results 101 to 110 of about 16,489,539 (298)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Impact of landscape disturbance on butterfly communities: Diversity, distance dependence, and neutral model predictions

open access: yesGlobal Ecology and Conservation
Recent theoretical work suggests that rainforest biotas are not primarily structured by environmental determinism but rather by stochastic processes. We sampled butterflies from primary and disturbed (logged, and burnt) forest landscapes and compared ...
Daniel F.R. Cleary   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

Towards a Revised Monte Carlo Neutral Particle Surface Interaction Model [PDF]

open access: yes, 2005
The components of the neutral- and plasma-surface interaction model used in the Monte Carlo neutral transport code DEGAS 2 are reviewed. The idealized surfaces and processes handled by that model are inadequate for accurately simulating neutral transport
Stotler, D. P.
core   +1 more source

Damselflies and dragonflies in distress: The impact of forest fires and logging on odonate assemblages

open access: yesEcological Indicators
We assessed the impact of logging and forest fires on the species richness, evenness, and structure of odonate assemblages located on the island of Borneo.
Daniel F.R. Cleary   +3 more
doaj   +1 more source

Construction and verification of a neutral layer offset model based on pressure elastic-plastic deformation

open access: yes工程科学学报, 2015
For the obvious neutral layer offset of a large cross-section bar in the two-roll straightening process,which has large impact on the roller type and the bar straightness accuracy,a neutral layer offset model was established based on the three-point ...
WANG Rong-jun   +5 more
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

open access: yesMolecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani   +7 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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