Results 121 to 130 of about 9,769 (296)

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

A Model-based Predictive Current Controller for a Back-to-Back Connected Multilevel Converter Aerospace Starter-Generator [PDF]

, 2016
The application of predictive current control to a multilevel converter is explored for application in an aerospace starter-generator system to investigate how such as system may be used to limit the harmonic distortion in the starter-generator’s ...
Foster, M.P., Stone, D., Williams, R.
core   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

A Traction Three-Phase to Single-Phase Cascade Converter Substation in an Advanced Traction Power Supply System

Energies, 2015
The advanced traction power supply system (ATPSS) is a new directional development for traction power supply systems, which can totally remove the neutral sections and effectively promote power quality.
Xiaoqiong He, Aiping Guo, Xu Peng, Yingying Zhou, Zhanghai Shi, Zeliang Shu   +5 more
doaj   +1 more source

Hierarchical Artificial Muscle with Nonlinear Elasticity for Antagonistic and Cyclic Robotics

Advanced Science, EarlyView.
We construct hierarchical muscles by plying nylon fibers around a heating wire. The hierarchical muscle shows a J‐shaped passive curve, which shows benefit in antagonistic muscle pair and work accumulation mechanism. We also develop a computational, first‐principle model to understand the physics of both active actuation stroke and passive J‐curve ...
Samuel Tsai, Liuyang Cheng, Ali Albazroun, Qiong Wang, Jeongmin Kim, Arman Tekinalp, Soonwook Kim, Charlie Simcox, Ryne Downing, Vagish Sivaramakrishnan, Grace Carsello, Miles Bimrose, Wonsik Eom, William P. King, Mattia Gazzola, Sameh Tawfick   +15 more
wiley   +1 more source

Understanding wind turbine power converter reliability under realistic wind conditions

IET Power Electronics
The reliability of wind turbine power converters is crucial for analyzing wind energy project costs, and for estimating maintenance and downtime. The published literature in this field relies on evaluating the reliability effect of wind speed to estimate
Sermed Alsaadi, Christopher J. Crabtree, Peter C. Matthews, Mahmoud Shahbazi   +3 more
doaj   +1 more source

Analysis, Design, and Performance Optimization of a Bidirectional Three-Level Neutral-Point-Clamped Dual-Bridge Series Resonant DC–DC Converter for Energy Storage Systems

IEEE Open Journal of Power Electronics
In this paper, an isolated bidirectional three-level neutral-point-clamped dual-bridge series resonant converter (3L-NPC-DBSRC) is proposed for the wide-voltage range dc-dc applications in energy storage systems, which consists of a neutral-point-clamped
Song Hu, Lei Han, Rui Wang, Chuan Sun, Yiwang Wang, Ming Lu, Xiaodong Li, Wu Chen   +7 more
doaj   +1 more source

Guidelines for Weighting Factors Adjustment in Finite State Model Predictive Control of Power Converters and Drives [PDF]

, 2009
INTERNATIONAL CONFERENCE ON INDUSTRIAL TECHNOLOGY () (.2009.VICTORIA, AUSTRALIA)Model Predictive Control with a finite control set has emerged as a promising control tool for power converters and drives.
Cortés, Patricio, García Franquelo, Leopoldo, Kouro, Samir, León Galván, José Ignacio, Rocca, Bruno La, Rodríguez, José, Vargas, René, Vázquez Pérez, Sergio   +7 more
core  

Ultrastrong TEMPO‐Oxidized Densified Bamboo via Interface Decoupling and Hierarchical Toughening

Advanced Science, EarlyView.
This study develops TEMPO‐oxidized densified bamboo that achieves ultrahigh strength and toughness by decoupling rigid hydrogen bonds into reversible van der Waals interactions. TEMPO oxidation reorganizes the cellulose hydrogen‐bonding network, facilitating energy dissipation via reversible interactions, thereby establishing a general strategy to ...
Ziyu Ba, Hongyun Luo, Jie Cui, Juan Guan, Zhaoliang Guo, Robert O. Ritchie   +5 more
wiley   +1 more source