Results 91 to 100 of about 27,926,146 (343)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Finite-Time Stability of Neutral Fractional Time-Delay Systems via Generalized Gronwalls Inequality
Abstract and Applied Analysis, 2014 This paper studies the finite-time stability of neutral fractional time-delay systems. With the generalized Gronwall inequality, sufficient conditions of the finite-time stability are obtained for the particular class of neutral fractional time-delay ...
Pang Denghao, Jiang Wei
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
, 1999 Abstract Their mixing makes them an excellent laboratory to look for very weak effects, like CP violation and CPT violation (Kostelecky 1998). The measurement of the tiny mass difference between the long-lived and the short-lived neutral kaons is one of the most precise measurements in particle physics.
Gustavo Castelo Branco +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Entropy generation analysis and thermal synergy efficiency in the T-shaped micro-kenics
HeliyonIn this work, three different twist angles of a micro helical insert in a T-shaped are studied numerically in order to evaluate the laminar steady flow behavior of Newtonian fluid in chaotic geometry. In the geometries under consideration, thermal mixing
Abdelkader Mahammedi +3 more
doaj +1 more source
Control of unstable steady states in neutral time-delayed systems
, 2008 We present an analysis of time-delayed feedback control used to stabilize an unstable steady state of a neutral delay differential equation. Stability of the controlled system is addressed by studying the eigenvalue spectrum of a corresponding ...
Blyuss, K. B. +3 more
core +2 more sources
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Bicyclo[3.2.0]carbocyclic Molecules and Redox Biotransformations: The Evolution of Closed-Loop Artificial Linear Biocatalytic Cascades and Related Redox-Neutral Systems. [PDF]
Molecules, 2023 Willetts A.
europepmc +1 more source