Results 221 to 230 of about 448,029 (330)

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Determinants of long-term SARS-CoV-2 immune responses in asymptomatic-to-moderate COVID-19 patients in sub-Saharan Africa. [PDF]

BMC Med
de Rioja VL, Goovaerts O, Vidal M, Amuasi J, Awuah AA, Mwan-Za-K'a CK, Mbala-Kingebeni P, Kibambe RN, Tshitamba M, Kazadi C, Yeshaneh WE, Hunde DB, Asres M, Tajebe F, Massinga MM, Maphossa V, Strauss R, Ascofare OM, Monnot F, Lassout NIZ, Musa A, ANTICOV-IMMUNO Consortium, Adriaensen W, Moncunill G.   +23 more
europepmc   +1 more source

Amine‐Functionalized Chitosan/dECM Composite Promotes Cutaneous Regeneration and Hair Follicle Activation by Regulating Oxidative Stress and Inflammation

Advanced Healthcare Materials, EarlyView.
An amine‐functionalized chitosan and hydrolyzed dECM composite promotes cutaneous regeneration by modulating oxidative stress and inflammatory pathways. The material accelerates wound closure and stimulates hair follicle activation in UV‐damaged cutaneous tissue.
Yu‐Jin Kim, Seokheon Hong, Jae Hwi Lee, Jongmin Lee, Jae Jun Kang, Jiseon Bae, Jino Kim, Dong‐Hwee Kim, Jin Yoo, Mi Sun Cha, Su Hee Kim, Youngmee Jung   +11 more
wiley   +1 more source

Viral glycoprotein-mediated entry and antibody-mediated immunity in HIV-1 and SARS-CoV-2 infection. [PDF]

Front Immunol
Grunst MW, Li W, Mothes W.
europepmc   +1 more source

Antibody neutralization assay with SARS-CoV-2 and SARS-CoV pseudovirus v1

, 2020
Bei Wang, Wen-Hsin Sandy Lee, Cheng‐I Wang   +2 more
openalex   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Mild COVID-19 elicits early functional plasmablasts and longterm memory B cells while sustaining neutralizing antibody titers

, 2021
Paola Martinez-Murillo, Barbara C. Meyer, Carlos Manzanas, Géraldine Blanchard‐Rohner, Angela Huttner, Isabella Eckerle, Maria Vono, Elodie von Dach, Jean Villard, Arnaud M. Didierlaurent, C.-A. Siegrist, Christiane S. Eberhardt   +11 more
openalex   +1 more source

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, EarlyView.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source

Potent neutralization by antibodies targeting the MPXV A28 protein. [PDF]

Nat Commun
Yefet R, Battini L, Hubert M, Rakayev K, Guivel-Benhassine F, Rattner N, Porrot F, Abramovitz L, Ostashinsky G, Ben-Shalom N, Postal J, Polonsky K, Ralph-Altman M, Sweed S, Korner T, Friedel N, Hagin D, Sprecher E, Fishelson Z, Kobiler O, Adler-Abramovich L, Schwartz O, Guardado-Calvo P, Freund NT.   +23 more
europepmc   +1 more source

Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2

, 2020
James Brett Case, Paul W. Rothlauf, Rita E. Chen, Zhuoming Liu, Haiyan Zhao, Arthur S. Kim, Louis-Marie Bloyet, Qiru Zeng, Stephen Tahan, Lindsay Droit, Ma. Xenia G. Ilagan, Michael A. Tartell, Gaya K. Amarasinghe, Jeffrey P. Henderson, Shane Miersch, Mart Ustav, Sachdev S. Sidhu, Herbert W. Virgin, David Wang, Siyuan Ding, Davide Corti, Elitza S. Theel, Daved H. Fremont, Michael Diamond, Sean P. J. Whelan   +24 more
openalex   +1 more source