Results 221 to 230 of about 266,471 (305)

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields. [PDF]

Adv Sci (Weinh)
Cheng J, Cale EM, Maghsoudi A, Sutton MS, Longo NS, Gillespie RA, Wang L, Kosik I, Chong S, Yasuhara A, Bylund T, Schön A, Tripathi P, Tsybovsky Y, Lei H, Morano NC, Lupatkin AB, Morton AJ, Lang ZC, Becker JE, Frascilla IR, Lee M, Li N, Liu C, Roark RS, Shen CH, Teng IT, Van Wazer DJ, Wang D, Wu L, Ahlsen G, Castro M, Du H, Ernandes MJ, Li T, Lin BC, Louder MK, McKee K, Merriam JS, O'Dell S, Ou L, Pletnev S, Prikryl D, Qiu Q, Rubin S, Sastry M, Schmidt SD, Shajahan A, Shiakolas AR, Srivatsan S, Zhang B, Zhou Q, Connors M, Gall JG, Guo Y, Huang RK, Huang Y, Koup RA, Lei QP, Mascola JR, Rawi R, Serebryannyy L, Shapiro L, Sheng Z, Ho DD, Wilson PC, Yewdell JW, Pierson TC, Kanekiyo M, Doria-Rose NA, Kwong PD, Zhou T.   +71 more
europepmc   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Single-Cell Sensitive Colorimetric pH Detection Based on Microscope Ratiometric Grayscale

ACS Omega
Shuo Zhou, Anqi Li, Linying Zhao, Yanwen Li, Xiaolong Xu, Yongdong Jin   +5 more
doaj   +1 more source

Directed evolution of a stem-helix-targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity. [PDF]

PLoS Pathog
Zhou P, Yuan M, Zhang Y, Limbo O, Song G, Zhao F, Liu H, He WT, Capozzola T, Callaghan S, Avillion G, Li X, Beutler N, Yong P, Anzanello F, Rogers TF, Burton DR, Jardine JG, Wilson IA, Andrabi R.   +19 more
europepmc   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

A conserved VP1-286 epitope governs neutralization and immune escape in Coxsackievirus A6. [PDF]

Front Immunol
Wu JH, Sun YH, Du YX, Wu J, Wang H, Wang WH, Guo J, Qian SS, Chen XQ, Shen S.   +9 more
europepmc   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Transposon Vectors Enable Accelerated Development of Cellular Assay Platforms for the Identification and Characterization of Anti-Viral Small-Molecule Cell-Entry Inhibitors and Neutralizing Antibodies. [PDF]

Biomedicines
Pißarreck M, Katsoutas K, Kinder CL, Stitz J.   +3 more
europepmc   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source