Results 241 to 250 of about 2,192,151 (309)

Development of bispecific antibodies with enhanced neutralization activity against tested SARS-CoV-2 Omicron subvariants. [PDF]

Front Immunol
Hsu CH, Chang TY, Chang YM, Lin SH, Chen TN, Hsu KH, You JJ.   +6 more
europepmc   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Venomics of the Anchor Coral Snake <i>Micrurus ancoralis</i>: Composition, Toxicological Profile, and Neutralization by Commercial Antivenom. [PDF]

Trop Med Infect Dis
Rey-Suárez P, Echavarría-Rentería JD, Gómez-Robles J, Pereañez JA, Saldarriaga-Córdoba M, Lomonte B, Fernández J, Núñez V.   +7 more
europepmc   +1 more source

Design and Engineering of an Artificial Bifunctional N‐Deacetylase/N‐Sulfotransferase for the Biosynthesis of N‐Sulfated Heparosan

Advanced Science, EarlyView.
An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi, Ruirui Xu, Daoan Wang, Guobin Yin, Xinjing Wang, Haiqin Chen, Guocheng Du, Jian Chen, Zhen Kang   +8 more
wiley   +1 more source

Effect of Amorphous Silicates on the Neutralization of Tricalcium Aluminate Hexahydrate Relevant to Bauxite Residue Treatment. [PDF]

Inorg Chem
Szabó Y, Asher M, Zahorán R, Papp J, Sebők D, Sipos P, Szabados M, Gräfe M, Kutus B.   +8 more
europepmc   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

[On classification of serological reactions and on determination of the neutralization reaction].

Voprosy virusologii, 1998
openaire   +1 more source

<i>In vitro</i> assessment of foot-and-mouth disease vaccine immunogenicity: advances, challenges, and ethical considerations. [PDF]

Front Vet Sci
Othusitse L, Kabelo TI, Nkwe KA, Seoke L, Fana EM, Lebani K.   +5 more
europepmc   +1 more source

Preparation and epitope mapping of broad-spectrum neutralizing monoclonal antibodies against economically important pestiviruses. [PDF]

Vet Res
Liu Z, Mi S, He S, Wu M, Bao F, Feng Y, Wang Z, Xu L, Pan X, Tu C, Li J, Gong W.   +11 more
europepmc   +1 more source

Trimeric Class I Viral Fusion Protein Vaccine Immunogens Using a Trimeric Autotransporter in a Killed Whole-Cell Bacteria Vaccine Platform: Applications to HIV MPER. [PDF]

Viruses
Quintero-Barbosa JS, Song Y, Mehl F, Mathur S, Livingston L, Shen X, Montefiori DC, Zeichner SL.   +7 more
europepmc   +1 more source