Results 1 to 10 of about 280,511 (189)
Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus [PDF]
Cell Reports, 2017 Summary: Drug combinations are synergistic when their combined efficacy exceeds the sum of the individual actions, but they rarely include ineffective drugs that become effective only in combination. We identified several “enabling pairs” of neutralizing
Katie A. Howell +16 more
doaj +3 more sources
iScience, 2022 Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding and ...
Fangzhu Zhao +22 more
doaj +1 more source
Nature Communications, 2022 SIVmac239 infection of macaques is a favored model of human HIV infection, but antibody-mediated protection for SIVmac239 is insufficiently understood.
Fangzhu Zhao +31 more
doaj +1 more source
The diversity of the glycan shield of sarbecoviruses related to SARS-CoV-2
Cell Reports, 2023 Summary: Animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
Joel D. Allen +8 more
doaj +1 more source
Cell Reports, 2022 Summary: Elicitation of HIV broadly neutralizing antibodies (bnAbs) is challenging because unmutated bnAb precursors are rare and seldom bind HIV envelope glycoprotein (Env) trimers.
Jeong Hyun Lee +13 more
doaj +1 more source
Platelet-collagen adhesion: evidence for participation of antigenically distinct entities. [PDF]
, 1984 Univalent antibody fragments prepared from a rabbit antiserum raised against whole human platelets completely inhibited adhesion of platelets to immobilized trimeric collagen in a defined, Mg2+-dependent, adhesion assay.
Barondes, SH, Shadle, PJ
core +2 more sources
Cell Reports, 2015 Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist in metastable pre-fusogenic states that may be stabilized by directed rational design. As recently reported, the conformationally fixed HIV-1 envelope glycoprotein
Shailendra Kumar Sharma +8 more
doaj +1 more source
Development of an experimental inactivated PRRSV vaccine that induces virus-neutralizing antibodies [PDF]
, 2009 Porcine reproductive and respiratory syndrome virus (PRRSV) can induce reproductive disorders and is involved in the porcine respiratory disease complex, causing tremendous economic losses to the swine industry.
Delputte, Peter +4 more
core +3 more sources
Cell Reports, 2016 A major advance in the search for an HIV vaccine has been the development of a near-native Envelope trimer (BG505 SOSIP.664) that can induce robust autologous Tier 2 neutralization.
Laura E. McCoy +18 more
doaj +1 more source
Efficient isolation of rare B cells using next-generation antigen barcoding
Frontiers in Cellular and Infection Microbiology, 2023 The ability to efficiently isolate antigen-specific B cells in high throughput will greatly accelerate the discovery of therapeutic monoclonal antibodies (mAbs) and catalyze rational vaccine development.
Jonathan Hurtado +36 more
doaj +1 more source