Results 211 to 220 of about 280,630 (308)

Enhanced Clearance of HIV-1 Broadly Neutralizing Antibody VRC07-523-LS During Viremia: Influences on Trial Design and Analysis. [PDF]

Clin Transl Sci
Smith NM, Ho BM, Bar KJ, Gama L, Dziubla G, Koup RA, Pensiero M, Serebryannyy L, Caskey M, Wilkin TJ, Wood TD, Morse GD, Venuto CS, Cha R, Ma Q.   +14 more
europepmc   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

High-affinity optimization potential of the virus neutralizing antibody with twin cysteine-stabilized complementarity-determining region 3. [PDF]

Front Cell Infect Microbiol
Li J, Zeng DD, Yin Q, Zhang S, Zhao DS, Zhang Y, Zhang Z, Tong F, Zhao ZP, Jiang T, Zhao GY, Dong G.   +11 more
europepmc   +1 more source

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source

Divalent HIV-1 gp120 Immunogen Exhibits Selective Avidity for Broadly Neutralizing Antibody VRC01 Precursors. [PDF]

Vaccines (Basel)
Bailey R, Kahoekapu K, To A, Mayerlen LI, Kae H, Manninen G, Haun BK, Berestecky JM, Shikuma C, Lehrer AT, MacPherson IS.   +10 more
europepmc   +1 more source

Neutralizing Anti-Drug Antibody [PDF]

, 2020
openaire   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Discovery and molecular mechanism of potent neutralizing antibody from humanized mice with respiratory syncytial virus. [PDF]

PLoS Pathog
Zhang Z, Feng R, Zhang L, Yang Q, Chen X, Wang X, Nie C, Peng W, Wang X, Zhu L, Guo Y, Sun Z.   +11 more
europepmc   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Mechanism for evolution of diverse autologous antibodies upon broadly neutralizing antibody therapy of people with HIV. [PDF]

Cell Rep
Kannan D, Wang E, Deeks SG, Lewin SR, Chakraborty AK.   +4 more
europepmc   +1 more source