Results 161 to 170 of about 274,076 (393)

Normal Granulocyte Colony-forming Cells in the Bone Marrow of Yemenite Jews With Genetic Neutropenia [PDF]

, 1973
Uri Mintz, Leo Sachs
openalex   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source

Neutropenia during treatment of rheumatoid arthritis with levamisole. [PDF]

, 1978
Geraint T. Williams, S.A. Johnson, Paul Dieppe, E.C. HUSKISSON   +3 more
openalex   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Neutropenia Associated with Cephapirin Therapy [PDF]

, 1972
Matthew E. Levison, José L. Bran, Joanne H. Jepson, Donald Kaye   +3 more
openalex   +1 more source

Real‐world comparative effectiveness and safety of Pertuzumab in patients with HER2+ metastatic breast cancer: A pan‐Canadian population‐based cohort study

International Journal of Cancer, EarlyView.
What's New? In Canada, complexities surrounding provincial cancer care and data access challenge the collection of robust multijurisdictional real‐world evidence (RWE) on cancer therapies. RWE, however, can provide critical insight into the safety and effectiveness of novel therapies. Here, for the Canadian Real‐world Evidence for Value of Cancer Drugs
Caroline E. Muñoz, Wei Fang Dai, Winson Y. Cheung, Claire de Oliveira, Reka E. Pataky, Philip Q. Ding, David A. Tran, Zeb Aurangzeb, Chenthila Nagamuthu, Ning Liu, Lynn Lethbridge, Carol McClure, Kim Vriends, Hui Xiong, Chris Folkins, Chandy Somayaji, Stuart Peacock, Riaz Alvi, Donna Turner, Carrie O'Conaill, Ted McDonald, Robin Urquhart, Cynthia Kendell, Jeff Dowden, Erin Strumpf, Avram Denburg, Jaclyn M. Beca, Rebecca E. Mercer, Mina Tadrous, Pam Takhar, Kelvin K. W. Chan, on behalf of the CanREValue Collaboration   +31 more
wiley   +1 more source

Real‐world study on fluoropyrimidine‐related toxicity outcomes in cancer patients with select DPYD variant alleles that received DPYD genotype‐guided dosing

International Journal of Cancer, EarlyView.
What's New? Fluoropyrimidines, a key component of chemotherapy regimens for a variety of solid tumors, can cause severe toxicity. Patients who have specific genetic variants in the DPYD gene, which encodes an enzyme that inactivates fluoropyrimidines, have increased susceptibility to this toxicity.
Sofía L. J. Peeters, Didier Meulendijks, Zerina Kadric, Sara Ibrovic, Geert‐Jan Creemers, Vanja Milosevic, Matthijs van de Poll, Lieke H. J. Simkens, Birgit A. L. M. Deiman, Hans Gelderblom, Henk‐Jan Guchelaar, Anna M. J. Thijs, Maarten J. Deenen   +12 more
wiley   +1 more source

Depression of bone marrow colony formation in gold-induced neutropenia. [PDF]

, 1975
Anthony Howell, J M Gumpel, R. W. E. Watts   +2 more
openalex   +1 more source

The association between additional radiotherapy after systemic chemotherapy and the prognosis of stage FIGO 2018 IVB cervical cancer

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Systemic platinum‐based chemotherapy is the first‐line treatment of choice for metastatic cervical cancer. While subsequent radiotherapy after primary chemotherapy is a potential option, its benefit remains unclear. This multicenter retrospective study aimed to evaluate whether post‐chemotherapy radiotherapy improves the prognosis of
Ai Miyoshi, Fumiaki Isohashi, Makoto Fujii, Tadashi Iwamiya, Masahiko Takemura, Yoshikazu Nagase, Takeshi Yokoi, Emi Yoshioka, Kimihiko Ito, Eri Yamabe, Kanji Masuhara, Tomoko Tsujie, Tadashi Kimura, Michiko Kodama   +13 more
wiley   +1 more source