Daunorubicin dose escalation from 45 to 60 mg/m2 provides no clinical benefit for AML patients aged 55–65. A dose of 45 mg/m2 should remain the preferred regimen for this population. ABSTRACT Daunorubicin dose optimization remains crucial for AML treatment.
Chunlin Zhou +15 more
wiley +1 more source
Frontline Febrile Neutropenia Antibiotic Treatment Across Institution Types: A Multicenter Survey Study. [PDF]
Castillo M, Gross D, Harding SJ.
europepmc +1 more source
Expanding Phenotype of GINS1 Deficiency: A Case Report and Review of the Literature
The authors present a novel case and review of individuals with GINS1 deficiency, causing severe growth restriction and combined immunodeficiency. Only the ninth case of this ultrarare disorder, it highlights the role of these variants in disease, glaucoma as a feature, and the possibility of immunodeficiency without infections in affected individuals.
Michael P. Mackley +6 more
wiley +1 more source
Adverse events in small dogs treated with a single dose of vinblastine. [PDF]
Matsuyama F +5 more
europepmc +1 more source
S1 Guideline on Infected Interdigital Intertrigo (also called Gram‐Negative Toe Web Infection)
Summary Infected interdigital intertrigo is an exudative, macerating, mixed infection of the toe webs in which gram‐negative bacteria (Pseudomonas aeruginosa and Enterobacterales) seem prevalent, but in which gram‐positive pathogens (Staphylococcus [S.] aureus, streptococci, enterococci) and fungi (dermatophytes, yeasts) also occur.
Christoph Zeyen +10 more
wiley +1 more source
Neutropenia Potentially Associated With Remifentanil Administered for Respiratory Drive Suppression: A Case Report. [PDF]
Watanabe H, Minami K, Takeuchi M.
europepmc +1 more source
Comparative efficacy and safety of individual short-acting versus long-acting granulocyte colony-stimulating factors, including biosimilars, for primary prophylaxis of chemotherapy-induced myelosuppression in breast cancer patients: a systematic review and network meta-analysis protocol. [PDF]
Bi X, Shu S, Tang K, Yin P, Chen Y.
europepmc +1 more source
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley +1 more source
Infection-Associated Transient Neutropenia Mimicking Methimazole-Induced Agranulocytosis in Graves' Disease: A Diagnostic Dilemma. [PDF]
Saiprasad S +3 more
europepmc +1 more source

