Results 71 to 80 of about 19,222,227 (292)

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

open access: yesAdvanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters   +12 more
wiley   +1 more source

Does the Mosaic Law Obligate Christians? The Fate of the Gentiles in Ḥizzuq ʾEmunah by 16th-Century Karaite Jewish Polemicist Isaac Ben Abraham of Troki

open access: yesReligions
Ḥizzuq ʾEmunah (Faith Strengthened), written by the 16th-century Karaite Jewish scholar Isaac ben Abraham of Troki (Polish–Lithuanian Commonwealth), was one of the most renowned Hebrew anti-Christian polemical works, meriting translation into most ...
Golda Akhiezer
doaj   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

open access: yesAdvanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum   +13 more
wiley   +1 more source

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

open access: yesAdvanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei   +17 more
wiley   +1 more source

Young children's perspectives of time: New directions for co‐constructing understandings of quality in ECEC

open access: yesBritish Educational Research Journal, EarlyView., 2023
Abstract Children's relationship with time in preschools is an under‐researched area. Young children rarely know how to measure time using a clock, but their experiences of time may contribute to understanding children's well‐being and debates about quality in preschools.
Kristín Dýrfjörð   +3 more
wiley   +1 more source

Identiteit en seksualiteit in die Nuwe Testament

open access: yesVerbum et Ecclesia, 2006
This contribution wants to provide a broad overview of sexuality in the New Testament. It provides broad thematic stripes, picturing the early Christians as sexual beings with a new identity in Christ.
GJ Steyn
doaj   +1 more source

A critical evaluation of Clifford Christians’s media ethics theory: a précis

open access: yesChurch, Communication and Culture, 2020
Clifford Christians, a leading authority in media ethics, first proposed the idea of constructing a new ethical theory for the field as early as 1977.
Robert Z. Cortes
doaj   +1 more source

Cryo‐EM and NMR Reveal a Membrane‐Gated Doc2B–Munc13‐1 Complex and a Helical Doc2B‐SNARE‐Binding Interface

open access: yesAdvanced Science, EarlyView.
Biophysical studies of Doc2B yield a cryo‐electron microscopy structure of its complex with the synaptic vesicle priming factor Munc13‐1 and its binding site to the SNARE complex that mediates synaptic vesicle fusion. These and other results suggest a novel model whereby Doc2 proteins regulate neurotransmitter release through sequential interactions ...
Cyrus T. Rastegar   +8 more
wiley   +1 more source

New Testament Paradigm of the Unity of Christians

open access: yesKairos (English Ed.), 2008
The intention of this article is to describe: first, the New Testament paradigm of unity, second, the New Testament nature of unity, and third, the New Testament teaching concerning the responsibility of leaders to maintain unity.
Miško Horvatek
doaj  

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

open access: yesAdvanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng   +6 more
wiley   +1 more source

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