Results 201 to 210 of about 3,407,275 (255)
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
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2016
Debunking the myth of the ageing time bomb, this timely book from the authors of <i>Retiring with Attitude</i> challenges our assumptions and stereotypes and demonstrates that we are capable of living better together longer in this new, older world.
Caroline Lodge +2 more
openaire +1 more source
Debunking the myth of the ageing time bomb, this timely book from the authors of <i>Retiring with Attitude</i> challenges our assumptions and stereotypes and demonstrates that we are capable of living better together longer in this new, older world.
Caroline Lodge +2 more
openaire +1 more source
Neurology, 2022
The pandemic is transforming neurology. Long COVID will linger, neurologic diseases will increase, and technology, artificial intelligence, and new virtual worlds will usher a new age of the brain and new roles for neurologists. The pandemic has compelled international collaboration, greatly increased communications, and accelerated drug and vaccines ...
openaire +2 more sources
The pandemic is transforming neurology. Long COVID will linger, neurologic diseases will increase, and technology, artificial intelligence, and new virtual worlds will usher a new age of the brain and new roles for neurologists. The pandemic has compelled international collaboration, greatly increased communications, and accelerated drug and vaccines ...
openaire +2 more sources
Positive aging: New images for a new age
Ageing International, 2001The gerontological literature in the social sciences has typically characterized the aging process in terms of decline, degeneration, and decrepitude. Comparatively little attention has been paid to the possibility of growth, generativity, and development in the last decades of life.
Gergen, M. M., Gergen, Kenneth J.
openaire +2 more sources