Results 1 to 10 of about 29,602,681 (295)

Building a Framework for a More Inclusive Healthcare System

Telehealth and Medicine Today, 2023
Objective: With the explosion in the use of telehealth technologies, it is essential to address the challenges in global telehealth inequity in order to create a path to healthcare equality.
Maria Palombini, Tiffany Vereen, Jahnahn Taghiani, Tanvi Chitre   +3 more
doaj   +1 more source

Early Versus Late Catheter Ablation of Atrial Fibrillation and Risk of Permanent Pacemaker Implantation in Patients With Underlying Sinus Node Dysfunction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Atrial fibrillation (AF) is associated with anatomical and electrical remodeling. Some patients with AF have concomitant sick sinus syndrome and may need permanent pacemaker (PPM) implantation.
Muhammad Umer Butt, Nazli Okumus, Ahmad Jabri, Charles Thomas, Yasir Tarabichi, Saima Karim   +5 more
doaj   +1 more source

Evolutionary Protection of Krüppel-Like Factors 2 and 4 in the Development of the Mature Hemovascular System

Frontiers in Cardiovascular Medicine, 2021
A properly functioning hemovascular system, consisting of circulating innate immune cells and endothelial cells (ECs), is essential in the distribution of nutrients to distant tissues while ensuring protection from invading pathogens.
David R. Sweet, David R. Sweet, David R. Sweet, Cherry Lam, Mukesh K. Jain, Mukesh K. Jain   +5 more
doaj   +1 more source

Randomized trial of a web-based nurse education intervention to increase discussion of clinical trials

Contemporary Clinical Trials Communications, 2021
Background: Clinical trials are a critical source of evidence for oncology care, yet very few patients participate. Among healthcare providers, nurses spend the most time with cancer patients and are the most highly trusted professionals.
Seunghee Margevicius, Barbara Daly, Mark Schluchter, Susan Flocke, Sharon Manne, Jessica Surdam, Sarah Fulton, Neal J. Meropol   +7 more
doaj   +1 more source

Image analysis reveals molecularly distinct patterns of TILs in NSCLC associated with treatment outcome

npj Precision Oncology, 2022
Despite known histological, biological, and clinical differences between lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), relatively little is known about the spatial differences in their corresponding immune contextures.
Ruiwen Ding, Prateek Prasanna, Germán Corredor, Cristian Barrera, Philipp Zens, Cheng Lu, Priya Velu, Patrick Leo, Niha Beig, Haojia Li, Paula Toro, Sabina Berezowska, Vipul Baxi, David Balli, Merzu Belete, David L. Rimm, Vamsidhar Velcheti, Kurt Schalper, Anant Madabhushi   +18 more
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Tutorial: using NEURON for neuromechanical simulations

Frontiers in Computational Neuroscience, 2023
The dynamical properties of the brain and the dynamics of the body strongly influence one another. Their interaction generates complex adaptive behavior. While a wide variety of simulation tools exist for neural dynamics or biomechanics separately, there
Chris Fietkiewicz, Robert A. McDougal, Robert A. McDougal, Robert A. McDougal, Robert A. McDougal, David Corrales Marco, Hillel J. Chiel, Hillel J. Chiel, Hillel J. Chiel, Peter J. Thomas, Peter J. Thomas, Peter J. Thomas, Peter J. Thomas, Peter J. Thomas   +13 more
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High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition

eLife, 2020
Serotonin receptors (5-HT3AR) play a crucial role in regulating gut movement, and are the principal target of setrons, a class of high-affinity competitive antagonists, used in the management of nausea and vomiting associated with radiation and ...
Sandip Basak, Arvind Kumar, Steven Ramsey, Eric Gibbs, Abhijeet Kapoor, Marta Filizola, Sudha Chakrapani   +6 more
doaj   +1 more source

Intracellular pH regulation by acid/base transporters in mammalian neurons

Frontiers in Physiology, 2014
Intracellular pH (pHi) regulation in the brain is important in both physiological and physiopathological conditions because changes in pHi generally result in altered neuronal excitability.
Vernon A. Ruffin, Ahlam I. Salameh, Walter F. Boron, Mark D. Parker, Mark D. Parker   +4 more
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Conformational transitions and allosteric modulation in a heteromeric glycine receptor

Nature Communications, 2023
Glycine receptors (GlyR) are a critical postsynaptic component of spinal neurons. Here, the auhtors present cryo-EM structures of a heteromeric GlyR in the presence of an antagonist, agonist and agonist with a positive allosteric modulator.
Eric Gibbs, Emily Klemm, David Seiferth, Arvind Kumar, Serban L. Ilca, Philip C. Biggin, Sudha Chakrapani   +6 more
doaj   +1 more source

METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events

Molecular Neurodegeneration, 2021
Background N6-methyladenosine (m6A) modification of RNA influences fundamental aspects of RNA metabolism and m6A dysregulation is implicated in various human diseases.
Fanpeng Zhao, Ying Xu, Shichao Gao, Lixia Qin, Quillan Austria, Sandra L. Siedlak, Kinga Pajdzik, Qing Dai, Chuan He, Wenzhang Wang, James M. O’Donnell, Beisha Tang, Xiongwei Zhu   +12 more
doaj   +1 more source