Results 151 to 160 of about 29,602,681 (295)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Allocation of Resources for Basic Research in a Mission Oriented Governmental Agency

Operations Research ...
Brown, Melvin (Creatorcre), Huettner, David (Creatorcre), Mantel, Samuel J. (Creatorcre), Friedel, Donald C. (Creatorcre), Dean, Burton V. (Creatorcre)   +4 more
core  

Mandibular Inflammatory Myofibroblastic Tumors: A Literature Review with a New Case Presentation. [PDF]

Curr Oncol
Benites C, Armosh K, Uribe Sanchez ED, Ruddocks LA, Dziegielewski PT.   +4 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Application of Pert in Plant Construction Scheduling in the Ohio Brass Company

Operations Research ...
Mathis, Samuel J., Jr. (Creatorcre), Huckfeldt, Vaughn E. (Creatorcre), Dean, Burton V. (Creatorcre)   +2 more
core  

Adenoid ameloblastoma of the mandible: report of a new case of a distinct type of odontogenic neoplasms. [PDF]

BMC Oral Health
Abou Madawi N, Abdou A, El Bahey N, Moussa M.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Analysis of Congestion Problems in UCDF Operations

Operations Research ...
Hartman, James K. (Creatorcre)
core  

TokenUNet: A new case for transformers integration in efficient and interpretable 3D UNets for brain imaging segmentation. [PDF]

PLoS One
Tshimanga LF, Zanola A, Del Pup F, Atzori M.   +3 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source