Results 141 to 150 of about 5,175,696 (290)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Integrating Quadrimalleolar Fractures of the Ankle in a Johannesburg Academic Center: A New Classification. [PDF]

Cureus
Nkosi C, Kyei P, Kagodora B.
europepmc   +1 more source

Aortic stenosis: new classification.

Journal of the American College of Cardiology, 2012
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Early prediction of bronchopulmonary dysplasia using new classification in high-risk preterm infants. [PDF]

Clin Exp Pediatr
Jeon GW.
europepmc   +1 more source

New GOLD classification

Rationale: Little is known about the longitudinal changes associated with using the 2013 update of the multidimensional GOLD strategy for chronic obstructive pulmonary disease (COPD).Objective: To determine the COPD patient distribution of the new GOLD proposal and evaluate how this classification changes over one year compared with the previous GOLD ...
Casanova, Ciro||, Marín, Jose M.||, Martínez-González, Cristina||, de Lucas-Ramos, Pilar||, Mir-Viladrich, Isabel, Cosio, Borja G.||, Peces-Barba, German||, Calle Rubio, Myriam||, Solanes García, Ingrid||, Agüero, Ramón, De Diego-Damia, Alfredo, Feu-Collado, Núria, Alfageme, Inmaculada||, Irigaray, Rosa, Balcells, Eva||, Llunell, Antònia, Galdiz, Juan Bautista, Marín, Margarita, Soler Cataluña, Juan José, Lopez-Campos, José Luis, Soriano, Joan B..||, de-Torres, Juan P., Calvo Bonachera, José, Lacárcel Bautista, Celia, Domenech, Adolfo, Marín Trigo, José María, González, C.M., Piqueras, B.G.C., Cabrera-Lopez, Carlos||, Sánchez Acosta, Alejandro, Abreu González, Juan, Miguel Campos, Elena, Marín, Alicia||, Moreno, Amalia, Márquez Pérez, Francisca Lourdes, Riesco Miranda, Juan Antonio, Rodríguez, Julia Tabara, Golpe, Rafael||, de Miguel Díez, Javier, García Río, Francisco, Díaz Lobato, Salvador   +40 more
openaire   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Fake news classificator

, 2019
Esta investigación se centrará en clasificar las noticias falsas según el estilo y el contenido. Además se implementará un servicio web para realizar predicciones de artículos de contenido en linea y a la vez reentrenarse con los artículos que no ha podido predecir correctamente.
openaire   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source