Results 191 to 200 of about 2,291,252 (241)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

An improved Wexler algorithm for electrical impedance tomography using finite element method and gradient based overrelaxation. [PDF]

Sci Rep
Jurgielewicz M, Walczyk CJ.
europepmc   +1 more source

Economic evaluations of screening and case-finding for Chronic Obstructive Pulmonary Disease (COPD): a systematic review. [PDF]

NPJ Prim Care Respir Med
Fan Y, Chen Q, Sun H, Bärnighausen T, Wang C, Yang T, Chen S.   +6 more
europepmc   +1 more source

Middle Meningeal Artery Embolization as a First-Line Therapy for Chronic Subdural Hematoma. [PDF]

Cureus
Jain R, Shah A, Mina D, Furlan AB, Al-Roubaie M.   +4 more
europepmc   +1 more source

Finding the Findings Behind the News

, 2002
openaire   +1 more source