Results 51 to 60 of about 21,961,066 (284)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Unleashing the inners strengths of University entrants
Ho Chi Minh City Open University Journal of Science - Social SciencesThis paper aimed to unleash the modular experiences of university freshmen during the onset of the Covid-19 pandemic. Using a transcendental phenomenological approach, the data were collected through individual phone interviews with fifteen university ...
Mary Jane Babalcon Cinco +1 more
doaj +1 more source
POSITIVE LIFE SPACE THROUGH FINDING NEW INTEGRATION BY PERSONALITY
Вестник Тамбовского университета. Серия: Гуманитарные науки, 2017 In a modern society a cardinal displacement of value and spiritual orientations has happened. This has lead to new significant changes of life space and devaluation of human identity.
E. A. Uvarov
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Finding New Hot Subdwarf Stars in SDSS Images
The Astronomical JournalHot subdwarf stars, located at the end of the blue horizontal branch, have a burning helium core, and are crucial for studying stellar structure. Currently, the number of known hot subdwarf star is relatively small.
Jiangchuan Zhang +8 more
doaj +1 more source
.Finding Nero: shining a new light on Romano-British sculpture
Internet Archaeology, 2013 This article discusses the use of 3D laser scanning as an objective means to record and identify damaged Roman portraits in stone, in this case three mutilated images recovered from Romano British contexts that can now be identified as being of the fifth
Miles Russell, Harry Manley
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Finding New News: Novelty Detection in Broadcast News
, 2005 The automatic detection of novelty, or newness, as part of an information retrieval system would greatly improve a searcher’s experience by presenting “documents” in order of how much extra information they add to what is already known instead of how similar they are to a user’s query.
Gaughan, Georgina, Smeaton, Alan F.
openaire +2 more sources