Results 91 to 100 of about 92,675 (316)

Influence of the details of topography onweather forecast – evaluation of HARMONIEexperiments in the Sochi Olympics domainover the Caucasian mountains

Frontiers in Earth Science, 2016
New fine-resolution surface elevation data was implemented intoHARMONIE-AROME-SURFEX Numerical Weather Prediction (NWP) system. Thegrid-scale mean orography, used as a basis of the model'sterrain-following vertical coordinate, as well as variables ...
Laura eRontu, Clemens eWastl, Sami eNiemela   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A new calculation of atmospheric neutrino fluxes [PDF]

Astroparticle Physics, 1994
Abstract Atmospheric neutrino fluxes have been computed directly from recent measurements of muon momentum spectra in the stratosphere. The results agree to within about 15% with the previous calculations by Barr, Gaisser and Stanev by another method, although they predict a somewhat different variation of flux with geomagnetic latitude.
openaire   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Evaluating the JULES land surface model energy fluxes using FLUXNET data [PDF]

, 2010
Surface energy flux measurements from a sample of ten FLUXNET sites selected to represent a range of climate conditions and biome types were used to assess the performance of the Hadley Centre land surface model (JULES).
Lloyd, Amanda, Shuttleworth, Jim, Lloyd, A., Pryor, M., Weedon, G.P., Blyth, E., Blyth, Eleanor, Gash, John, Weedon, Graham P., Gash, J.H.C., Shuttleworth, J., Pryor, Matthew, Lloyd, A.J.   +12 more
core   +1 more source

Research on B2O3–NaF–SiO2 fluxes for improved fusion defects and mechanical properties of A7N01 alloy with unequal thickness

Journal of Materials Research and Technology
In the aerospace industry, the additive manufacturing of aluminum alloys has encountered significant challenges owing to fusion defects. In this work, the B2O3–NaF–SiO2 fluxes are employed for the first time to improve the fusion defects and mechanical ...
Ning Cui, Yaojie Chao, Yu Tang, Qian Luo, Desheng Li, Sitong Zang, Hai Lin   +6 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Methane emissions variability from a Welsh patterned raised bog [PDF]

, 2011
PhDThis work investigated the variability of CH4 emissions from a Welsh raised bog Cors Fochno and evaluated the role of ebullition as a mechanism of CH4 flux to the atmosphere.
Stamp, Imelda
core