Results 51 to 60 of about 2,020 (217)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The impact of the digital technological revolution on the development of crisis management theory

Модернизация, инновация, развитие
Purpose: is to identify the main directions of changing the theory of crisis management of companies under the influence of digitalization based on the analysis of technological transformations in the economy and institutional prerequisites.Methods: to ...
E. P. Kochetkov
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Theory of institutions by the New Institutional Economics and institutional economic reforms in Vietnam

Science & Technology Development Journal - Economics - Law and Management, 2018
Economic institutions play an indispensable role in creating an impetus for economic development. Although the concepts of institutions and economic institutions are not new in Vietnam, their connotation and nature remain controversial. This paper aims to clarity the connotation and the nature of institutions and economic institutions, thereby ...
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Poltekkes Kemenkes Malang’s Organizational Response In Facing The Implementation of Performance-Based Remuneration System (A Case Study on Public Service Institution within Resource Dependence Theory Perspective andNew Institutional Sociology)

JABE (Journal of Accounting and Business Education), 2019
This study is aimed at revealing the organizational response of Polkesma in facing pressure on the implementation of remuneration system and the way to continue the sustainability of remuneration system through Resource Dependence Theory and New ...
Mintarsih Puji Rahayu, Ali Djamhuri, Rosidi Rosidi   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Reformy instytucjonalne Unii Gospodarczej i Walutowej po 2010 r. – ocena zasadności i efektywności wprowadzonych rozwiązań na gruncie teorii optymalnych obszarów walutowych

Politeja
INSTITUTIONAL REFORMS OF THE ECONOMIC AND MONETARY UNION IMPLEMENTED AFTER 2010: THE EFFECTIVENESS OF NEW ARRANGEMENTS ON THE GROUNDS OF THE THEORY OF OPTIMUM CURRENCY AREAS The economic shocks over the last 15 years revealed low effectiveness of ...
Marta Wajda-Lichy
doaj   +1 more source

Digitalization of revenue mobilization in an emerging economy: the new Institutional Theory perspective

International Journal of Information Systems and Project Management, 2023
This study sought to explore how the institutional environment comprising regulative, normative, and cognitive factors influences the use of technology in revenue mobilization in the public sector of an emerging economy.
Nora Agyei-Ababio, Eric Ansong, Kwame Assa-Agyei   +2 more
doaj