Results 231 to 240 of about 19,089,370 (314)

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

Changes in the food environment surrounding schools in four New Jersey school districts between school years 2012-13 and 2019-20. [PDF]

Prev Med
Acciai F, Ganderats-Fuentes M, Ohri-Vachaspati P.   +2 more
europepmc   +1 more source

stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics

Advanced Science, EarlyView.
stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang, Yan Wang, Luonan Chen, Chunman Zuo   +3 more
wiley   +1 more source

Trends in cannabis use in New Jersey: Effects of COVID-19 and cannabis legalization. [PDF]

J Am Coll Emerg Physicians Open
Kane JP, Ames A, Patel RV, Voity K, Narine R, Perotte R, Gelman S, McCarthy D, Nemetski SM.   +8 more
europepmc   +1 more source

Electromagnetic Radiation Stimulated Learning in Perovskite Nickelates

Advanced Science, EarlyView.
ABSTRACT Biological plasticity refers to the ability of synapses to strengthen or weaken over time. These adaptive properties play a fundamental role in learning and memory, spanning many orders of magnitude in timescales. Short‐term plasticity (STP) arises from rapid correlative activity, while long‐term plasticity (LTP) is governed by slower ...
Ranjan Kumar Patel, Kabir Zama, Matthew Smart, Ramya Eathirajan, Ivan Seskar, Narayan Mandayam, Guangxin Ni, Martin Mönnigmann, Shriram Ramanathan   +8 more
wiley   +1 more source

Radiative cooling in New York/New Jersey metropolitan areas by wildfire particulate matter emitted from the Canadian wildfires of 2023. [PDF]

Commun Earth Environ
Kelesidis GA, Moularas C, Parhizkar H, Calderon L, Tsiodra I, Mihalopoulos N, Kavouras I, Korras-Carraca MB, Hatzianastassiou N, Georgopoulos PG, Cedeño Laurent JG, Demokritou P.   +11 more
europepmc   +1 more source

Identification Checks and Underage Sales of Tobacco Products in New Jersey, 2019-2022.

JAMA Netw Open
Kong AY, Hrywna M, Ackerman C, Lee JGL, Delnevo CD.   +4 more
europepmc   +1 more source

The Camden Study-A Pregnancy Cohort Study of Pregnancy Complications and Birth Outcomes in Camden, New Jersey, USA. [PDF]

Nutrients
Shiau S, Chen X, April-Sanders A, Francis EC, Rawal S, Hansel M, Adeyemi K, Rivera-Núñez Z, Barrett ES.   +8 more
europepmc   +1 more source