Results 291 to 300 of about 7,083,291 (346)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Six New 14-Oxygenated Taxanes from the Cell Cultures of Taxus × Media

open access: green
Yuxin Wang   +4 more
openalex   +1 more source
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News Media and New Media

Media Asia, 2008
AbstractMy topic is “News Media and New Media”, a battlefield view of professional practice, ethics, media policy and the impacts of converging digital technology and globalisation. Before I advance into the impacts of new media and globalisation, I propose that we first re-examine the implicit assumption that all is well with news in traditional media!
openaire   +1 more source

New Media, New Media literacy, new methods in education

2013 IEEE 63rd Annual Conference International Council for Education Media (ICEM), 2013
The rapid proliferation of the concept of New Media and the attendant frequently controversial interpretations and research results motivate a scholarly overview of the possibilities of implementing the respective achievements in the teacher training process.
openaire   +1 more source

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