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Effect of spatial inhomogeneities on the membrane surface on receptor dimerization and signal initiation

Frontiers in Cell and Developmental Biology, 2016
Important signal transduction pathways originate on the plasma membrane, where microdomains may transiently entrap diffusing receptors. This results in a non-random distribution of receptors even in the resting state, which can be visualized as clusters ...
Romica Kerketta +9 more
doaj +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner +14 more
wiley +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

Arthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source

The mitochondrial genome of the planorbid snail Planorbella duryi

Mitochondrial DNA. Part B. Resources, 2018
The complete mitochondrial genome of a freshwater planorbid snail, Planorbella duryi (Mollusca, Gastropoda) was recovered from de novo assembly of genomic sequences generated with the Illumina NextSeq500 platform. The P.
Jonathan H. Schultz +25 more
doaj +1 more source

Linked hydrologic and social systems that support resilience of traditional irrigation communities [PDF]

Hydrology and Earth System Sciences, 2015
Southwestern US irrigated landscapes are facing upheaval due to water scarcity and land use conversion associated with climate change, population growth, and changing economics.
A. Fernald +11 more
doaj +1 more source

Differential Item Functioning on the Patient Health Questionnaire 8 by Disease Subtype, Language, Sex, and Age Among People With Systemic Sclerosis: A Scleroderma Patient‐Centered Intervention Network Cohort Study

Arthritis Care &Research, EarlyView.
Objective Somatic items used in depression assessments can potentially overlap with symptoms related to physical illness, including systemic sclerosis (SSc). No studies have looked at whether somatic depression items may be influenced by diffuse versus limited SSc disease subtypes, which are associated with varying degrees of symptom presentation.
Sophie Hu +110 more
wiley +1 more source

Towards an incoherent convergence science: diverse economies, crises, and recoveries, and the hope for better futures

Ecology and Society
Here, we argue for a critical approach to convergence science: one that develops collaborative problem-solving for pressing contemporary crises. We ask for researchers to encounter spaces where diverse epistemological and ontological perspectives can ...
Manuel R Montoya +4 more
doaj +1 more source

GROWTH, MORTALITY AND PRODUCTION OF BROWN AND RAINBOW TROUT IN NEW MEXICO STREAMS [PDF]

Croatian Journal of Fisheries, 1995
Thirty-two representative trout sites in 15 high elevation New Mexico streams (1,661 - 2560 m above sea level) were sampled in 1988 and 1989. Fish was captured by consecutive removal via electrofishing in net-blocked segments from 65 to 160 m long ...
S Leiner
doaj

Exposure to Virtual Social Stimuli Modulates Subjective Pain Reports

Pain Research and Management, 2014
BACKGROUND: Contextual factors, including the gender of researchers, influence experimental and patient pain reports. It is currently not known how social stimuli influence pain percepts, nor which types of sensory modalities of communication, such as ...
Jacob M Vigil +3 more
doaj +1 more source

Current Tracking Adaptive Control of Brushless DC Motors

International Journal of Adaptive Control and Signal Processing, EarlyView.
In this paper, the current tracking for Brushless Direct Current motors is approached considering uncertainty in the parameters of the motor's model. An adaptive control scheme to compensate electrical parameters uncertainty is proposed without requiring any knowledge of the mechanical parameters.
Fernanda Ramos‐García +3 more
wiley +1 more source

human–wildlife conflicts
mule deer
medicine general

arizona