Results 21 to 30 of about 204,316,318 (222)

Other title: Report of the chief juvenile court probation officer of the state of Connecticut for ...; Other title: Volume for 1940 has title: Connecticut children in court : the report of the Legislative Council of the state of Connecticut for the fiscal year ending ... and the calendar year ending ...

, 1935
Annual; Report year varies; issue for calendar year ending 1940 includes fiscal year ending June 30, 1940.; Volumes for 1931-1933 issued by the Bureau of Child Welfare; volumes for 1934- by the Office of Commissioner of ...
Connecticut. Bureau of Child Welfare.
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Other title: Report of the chief juvenile court probation officer of the state of Connecticut for ...; Other title: Volume for 1940 has title: Connecticut children in court : the report of the Legislative Council of the state of Connecticut for the fiscal year ending ... and the calendar year ending ...

, 1931
Annual; Report year varies; issue for calendar year ending 1940 includes fiscal year ending June 30, 1940.; Volumes for 1931-1933 issued by the Bureau of Child Welfare; volumes for 1934- by the Office of Commissioner of ...
Connecticut. Bureau of Child Welfare.
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Other title: Report of the chief juvenile court probation officer of the state of Connecticut for ...; Other title: Volume for 1940 has title: Connecticut children in court : the report of the Legislative Council of the state of Connecticut for the fiscal year ending ... and the calendar year ending ...

, 1939
Annual; Report year varies; issue for calendar year ending 1940 includes fiscal year ending June 30, 1940.; Volumes for 1931-1933 issued by the Bureau of Child Welfare; volumes for 1934- by the Office of Commissioner of ...
Connecticut. Bureau of Child Welfare.
core   +1 more source

Management and Operation Transformation of Urban Park Green Spaces from the Perspectives of Public Goods Provision and Fiscal Sustainability

Fengjing Yuanlin
ObjectiveThe research investigates the systemic transformation of urban park green space management and operation in China from the dual perspectives of public goods provision and fiscal sustainability.
Peiyi JIA
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Tagungsband zur 2. Tierwohltagung des Promotionsprogramms „Animal Welfare in Intensive Livestock Production Systems“

, 2019
Am 17. & 18.10.2019 fand in der alten Mensa am Wilhelmsplatz in Göttingen die 2. Tierwohltagung statt, organisiert von den DoktorandInnen des Promotionsprogramms „Animal Welfare in Intensive Livestock Production Sytems“.
Promotionsprogramm „Animal Welfare in Intensive Livestock Production Systems“
core   +1 more source