Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Unpacking the importance of intangible skills in new product development and sustainable business performance; strategies for marketing managers. [PDF]
PLoS One, 2020 Ali S, Li G, Yang P, Hussain K, Latif Y.
europepmc +1 more source
An evaluation of the Product Development Partnership Programme between New Zealand businesses and Institute of Technology and Engineering, Massey University : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Product Development at Massey University [PDF]
, 2002 Some text cut off from Appendix IX-This masterate thesis, An Investigation of The Effectiveness of the Product Development Partnership Programme Between New Zealand Businesses and Massey University, is the final report of a masters research undertaken ...
Lim, Siaw-Hui
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Eyes on New Product Development. [PDF]
J Ocul Pharmacol Ther, 2016 Novack GD.
europepmc +2 more sources
Customer empowerment in new product development [PDF]
, 2012 Companies have traditionally taken responsibility for deciding what products and product innovations are offered to customers. However, a growing number of companies are turning this relationship on its head by asking customers not only for help in ...
Fuchs, C. (Christoph) +1 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Impact of Patenting on New Product Introductions in the Pharmaceutical Industry [PDF]
Since Comanor and Scherer (1969), researchers have been using patents as a proxy for new product development. In this paper, we reevaluate this relationship by using novel new data.
Higgins, Matthew, Stuart, Graham
core +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source