Guide to Good Distribution Practice of Medicinal Products for Human Use
, 2021 The purpose of this document is to provide additional clarification to wholesalers and brokers located in Ireland regarding the Guidelines of 7 March 2013 on Good Distribution Practice of Medicinal Products for Human Use (2013/C 68/01). These guidelines,
Health Products Regulatory Authority (HPRA)
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Impact of red-to-blue LED light ratios on the yield and phytochemistry of leafy green amaranths
Frontiers in Plant ScienceLeafy green amaranth (Amaranthus tricolor) is a crop of global importance due to its vigorous growth in resource-limited environments and rich nutritional content.
Tori Rosen +3 more
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Guide for National Scientific and Regulatory Advice
, 2023 The aim of Health Products Regulatory Authority (HPRA) national scientific and regulatory advice is to support the development of new or existing human medicinal products.
Health Products Regulatory Authority (HPRA)
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A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Copper salt of a DABCO-based molten salt: a high-performance catalyst in the one-pot synthesis of 3,4-dihydropyrimidine and polyhydroquinoline derivatives. [PDF]
RSC Adv, 2023 Fekrat N, Mazloumi M, Shirini F.
europepmc +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Prices of New Mexico farm and ranch products
, 2012 Bulletin containing data on prices received by New Mexico farmers and ranchers for various agricultural products over a 38-year ...
Cockerill, P. W. (Percy Walter); Daniels, Fred; Christeson, R. R.
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Guide to New Applications and Variations to Manufacturer’s Authorisations
, 2022 This document provides guidance on applying to the HPRA for a new manufacturer’s authorisation or to vary an existing manufacturer’s authorisation. This guide should be read in conjunction with the following relevant application forms: - Application for
Health Products Regulatory Authority (HPRA)
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