Per- and Polyfluoroalkyl Substances in Cosmetics and Personal Care Products: State of the Art in Human Exposure. [PDF]
Abballe A +5 more
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Correction: Genome mining guided identification of new furo[3,2‑c]pyridones phaeopyridones A-C from the endophytic fungus Phaeobotryon negundinis 12020. [PDF]
Ye K +15 more
europepmc +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
No Added Sugar Mandate for the Nutrition Information Panel in Australia: A Missed Policy Opportunity for Early-Life Nutrition? [PDF]
Fleming CAK, Smith B, Kelly B, Kent K.
europepmc +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Regulatory Science for Veterinary Therapeutic Innovation: A Comparative Analysis of Drug Development Incentives Within the One Health Framework. [PDF]
Hong S, Lee SM.
europepmc +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source

